Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART)
Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART)
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DOI：
10.1016/j.neuroimage.2008.05.046
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发表时间：
2008-08-15
期刊：
影响因子：
5.7
通讯作者：
Detre, John A.
中科院分区：
文献类型：
--
作者：
Rao, Hengyi;Korczykowski, Marc;Detre, John A.
人们越来越多地致力于了解风险过程中决策的神经机制，但对自愿选择对风险承担的影响知之甚少。气球模拟风险任务(BART)，受试者将一个可以变大或爆炸的虚拟气球充气[Lejuez，C.W.，Read，J.P.，Kahler，C.W.，Richards，J.B.，Ramsey，S.E.，Stuart，G.L.，Strong，D.R.，Brown，R.A.，2002。风险承担的行为指标的评估：气球模拟风险任务。精神病患者。APPL8，75-84]，提供了评估人类冒险倾向和行为的所有生态有效模型。在本研究中，我们将这一任务修改为在功能磁共振成像(FMRI)中使用，并在所有主动选择模式和被动不选择模式下执行该任务，以检查人脑中自愿和非自愿冒险的神经关联。主动选择任务中的自愿风险与中脑边缘-额叶区域的强烈激活有关，包括中脑、腹侧和背侧纹状体、前脑岛、背外侧前额叶皮质(DLPFC)和前扣带回/内侧额叶皮质(ACC/MFC)，以及视觉通路区域的激活。然而，在被动无选择任务中，没有观察到这些中脑边缘-额叶激活模式存在非自愿风险。决策与右侧DLPFC的神经活动有关。这些发现证明了改进的BART范式在fMRI期间用于评估人类大脑中的冒险行为的有效性，并表明在冒险过程中大脑中脑边缘-额叶通路的招募取决于冒险者的代理。目前的范例可以扩展到病理性人群，以确定他们受损的危险行为的特定神经成分。(C)2008 Elsevier Inc.保留所有权利。
Increasing effort has been devoted to understanding the neural mechanisms underlying decision making during risk, yet little is known about the effect Of Voluntary choice on risk taking. The Balloon Analog Risk Task (BART), in which subjects inflate a virtual balloon that can either grow larger or explode [Lejuez, C.W., Read,J.P., Kahler, C.W., Richards, J.B., Ramsey, S.E., Stuart, G.L., Strong, D.R., Brown, R.A., 2002. Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task BART J. Exp. Psychol. Appl. 8, 75-84], provides all ecologically valid model to assess human risk taking propensity and behaviour. In the present study, we modified this task For use during functional magnetic resonance imaging (fMRI) and administered it in both ail active choice mode and a passive no-choice mode in order to examine the neural correlates of voluntary and involuntary risk taking in the human brain. Voluntary risk in the active choice task is associated with robust activation in mesolimbic-frontal regions, including the midbrain, ventral and dorsal striatum, anterior insula, dorsal lateral prefrontal cortex (DLPFC), and anterior cingulate/medial frontal cortex (ACC/MFC), in addition to activation in visual pathway regions. However, these mesolimbic-frontal activation patterns were not observed for involuntary risk in the passive no-choice task. Decision making was associated with neural activity in the right DLPFC. These findings demonstrate the utility of the modified BART paradigms for using during fMRI to assess risk taking in the human brain, and suggest that recruitment of the brain mesolimbic-frontal pathway during risk-taking is Contingent upon the agency of the risk taker. The present paradigm may be extended to pathological Populations to determine the specific neural components of their impaired risk behavior. (C) 2008 Elsevier Inc. All rights reserved.