In vivo gene expression: contributions to infection, virulence, and pathogenesis.
In vivo gene expression: contributions to infection, virulence, and pathogenesis.
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体内基因表达：对感染、毒力和发病机制的贡献。
DOI：
10.1007/978-3-642-80451-9_1
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发表时间：
1998
影响因子：
--
通讯作者：
Mahan,MJ
中科院分区：
文献类型：
--
作者：
Conner,CP;Heithoff,DM;Mahan,MJ
病原菌的特征在于它们能够在宿主细胞或液体中增殖，而这些宿主细胞或液体是禁止病原菌的。从这个角度来看，导致这些部位生长和持久性增强的细菌产物是决定微生物致病潜力的关键属性（Falkow 1996;Heithoffet al. 1997）。许多有助于这种独特能力的毒力决定因子具有共同的表型，即，在宿主组织中诱导。在这篇综述中，我们将描述两种互补的遗传策略，开发inSalmonella typhimurium，允许分离细菌基因诱导或感染过程中所需的。这些基因及其编码产物的鉴定为了解它们对感染、毒力和发病机制的作用提供了一种手段。
Pathogenic bacteria are distinguished by their ability to proliferate within host cells or fluids that are forbidden to commensal species. Viewed from this perspective, bacterial products that lead to enhanced growth and persistence at these sites are key attributes that determine a microbe’s pathogenic potential (Falkow1996;Heithoffet al. 1997). Many virulence determinants that contribute to this unique ability share a common phenotype, i.e., induction in host tissues. In this review, we will describe two complementary genetic strategies developed inSalmonella typhimuriumthat allow the isolation of bacterial genes induced or required during infection. The identification of such genes and the products they encode provides a means to understand their contributions to infection, virulence, and pathogenesis.