The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival

The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival
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DOI：
10.1083/jcb.201807127
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发表时间：
2020-01
期刊：
The Journal of Cell Biology
影响因子：
--
通讯作者：
A. Schulz;Y. Sekine;Motunrayo J Oyeyemi;Alexander Abrams;Manasa Basavaraju;S. M. Han;Marco Groth;H. Morrison;S. Strittmatter;Marc Hammarlund
A. Schulz;Y. Sekine;Motunrayo J Oyeyemi;Alexander Abrams;Manasa Basavaraju;S. M. Han;Marco Groth;H. Morrison;S. Strittmatter;Marc Hammarlund
中科院分区：
其他
文献类型：
--
作者：
A. Schulz;Y. Sekine;Motunrayo J Oyeyemi;Alexander Abrams;Manasa Basavaraju;S. M. Han;Marco Groth;H. Morrison;S. Strittmatter;Marc Hammarlund

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GDPGP 1及其C.线虫同源物MCP-1被鉴定为神经元细胞中的新的应激反应基因。应激诱导的GDPGP 1/mcp-1下调可降低细胞糖原水平，并导致不同物种的缺氧敏感性和神经退行性变。
GDPGP1 and its C. elegans homologue mcp-1 are identified as novel stress-responsive genes in neuronal cells. Stress-induced down-regulation of GDPGP1/mcp-1 reduces cellular glycogen levels and contributes to hypoxia sensitivity and neurodegeneration across species.