Cell Size Regulation in Bacteria
Cell Size Regulation in Bacteria
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DOI：
10.1103/physrevlett.112.208102
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发表时间：
2014-05-23
影响因子：
8.6
通讯作者：
Amir, Ariel
中科院分区：
文献类型：
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作者：
Amir, Ariel
各种细菌，如典型的革兰氏阴性大肠杆菌或充分研究的革兰氏阳性枯草芽孢杆菌，在它们的体积大约加倍后对称分裂。它们分裂时的大小不是恒定的，但通常分布在一个狭窄的范围内。在这里，我们提出了一个易于分析的细胞大小控制模型，并计算细胞大小和分裂时间分布，以及这些变量之间的相关性。我们提出了从实验数据中提取模型参数的方法，并表明现有的E。大肠杆菌支持部分大小控制，一个特别的解释是：细胞试图从DNA复制开始到下一个起始事件增加恒定的体积。这一假设解释了实验观察到的母细胞和子细胞之间的相关性以及大小对生长速率的指数依赖性。
Various bacteria such as the canonical gram negative Escherichia coli or the well-studied gram positive Bacillus subtilis divide symmetrically after they approximately double their volume. Their size at division is not constant, but is typically distributed over a narrow range. Here, we propose an analytically tractable model for cell size control, and calculate the cell size and interdivision time distributions, as well as the correlations between these variables. We suggest ways of extracting the model parameters from experimental data, and show that existing data for E. coli supports partial size control, and a particular explanation: a cell attempts to add a constant volume from the time of initiation of DNA replication to the next initiation event. This hypothesis accounts for the experimentally observed correlations between mother and daughter cells as well as the exponential dependence of size on growth rate.