Variation of interleukin 8 -251 A>T polymorphism in worldwide populations and intra-ethnic differences in Japanese populations.
Variation of interleukin 8 -251 A>T polymorphism in worldwide populations and intra-ethnic differences in Japanese populations.
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DOI：
10.1016/j.cca.2006.08.023
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发表时间：
2007-02
期刊：
影响因子：
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通讯作者：
J. Fujihara;K. Shiwaku;T. Yasuda;I. Yuasa;H. Nishimukai;R. Iida;H. Takeshita
中科院分区：
文献类型：
--
作者：
J. Fujihara;K. Shiwaku;T. Yasuda;I. Yuasa;H. Nishimukai;R. Iida;H. Takeshita
背景白细胞介素-8（IL-8）是趋化因子家族的一员。IL-8基因具有多态性，IL-8 − 251 A>T基因型与吸烟行为和癌症进展相关。蒙古族和朝鲜族群体的对向双引物PCR检测（PCR-CTPP）分析：日本的PTSA亚群分析显示IL 8 −251 T等位基因的频率从北到南增加。在5个群体中，日本人的突变等位基因频率最高，其次是土耳其人。日本人的分布模式与蒙古人和朝鲜人不同。在Ovambo人群中，未发现突变等位基因纯合子个体，突变等位基因频率最低，与冈比亚人相似。CONCLUSION本研究首次证明了日本人群IL-8 − 251 A>T多态性的县间差异以及IL-8 −251 A>T多态性在全球分布中存在一定的遗传异质性。分布结果可能有助于确定IL 8 −251 A>T多态性作为全球人群吸烟行为标记的真正意义。
BACKGROUNDInterleukin-8 (IL8) is a member of the family of chemokines. The IL8 gene has polymorphic variations, and the genotype of IL8 −251 A>T is associated with smoking behavior and cancer progression.METHODIL8 −251 A>T polymorphism were investigated in Japanese, from 5 different areas, in Ovambo, Turkish, Mongolian and Korean populations by PCR with confronting 2-pair primers (PCR–CTPP) analysis.RESULTSA subpopulation analysis of Japan revealed a north-to-south increase in the frequency of the IL8 −251 T allele. Among the 5 groups, the Japanese showed the highest frequency of mutant allele followed by the Turks. The distribution pattern in the Japanese was different from those of Mongolians and Koreans. In the Ovambo population, no mutant allele homozygote subject was found and the frequency of mutant alleles was the lowest, similar to that in Gambians.CONCLUSIONThe present study is the first to demonstrate the Japan population inter-prefecture differences in IL8 −251 A>T polymorphism as well as a certain genetic heterogeneity in the worldwide distribution of IL8 −251 A>T polymorphism. The distribution results may help define the true significance of IL8 −251 A>T polymorphism as a marker for smoking behavior in populations worldwide.