Understanding melanoma stem cells.
Understanding melanoma stem cells.
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DOI：
10.2217/mmt.15.4
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发表时间：
2015
影响因子：
3.6
通讯作者：
Fujita M
中科院分区：
文献类型：
--
作者：
Nguyen N;Couts KL;Luo Y;Fujita M
肿瘤是令人难以置信的多样化，包含许多不同的细胞亚群。肿瘤干细胞（CSC）亚群负责肿瘤发生的许多方面，并且已被证明在黑色素瘤的发生、进展、耐药性和转移中起重要作用。然而，越来越清楚的是，肿瘤细胞群体是动态的，并且可以受到许多因素的影响，例如来自肿瘤微环境和体细胞进化的信号。这篇综述将介绍目前对CSC的理解以及识别和表征这种动态细胞群的挑战。黑色素瘤干细胞的已知特征和功能，以及这些细胞在黑色素瘤中的治疗靶向潜力，将进行讨论。
Tumors are incredibly diverse and contain many different subpopulations of cells. The cancer stem cell (CSC) subpopulation is responsible for many aspects of tumorigenesis and has been shown to play an important role in melanoma development, progression, drug resistance and metastasis. However, it is becoming clear that tumor cell populations are dynamic and can be influenced by many factors, such as signals from the tumor microenvironment and somatic evolution. This review will present the current understanding of CSCs and the challenges of identifying and characterizing this dynamic cell population. The known characteristics and functions of melanoma stem cells, and the potential for therapeutic targeting of these cells in melanoma, will be discussed.