Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis.
Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis.
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DOI：
10.1155/2016/4328697
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Narayan G
中科院分区：
文献类型：
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作者：
Mishra D;Singh S;Narayan G
人CD10抗原是单次、II型跨膜、100kD细胞表面糖蛋白，属于肽酶M13家族。 CD10 是一种广泛表达于不同类型细胞的细胞表面胞外酶，在常见的急性淋巴细胞白血病中被鉴定为癌症特异性抗原。早些时候，它仅用作细胞表面标记物来识别和区分血液恶性肿瘤。后来，据报道它存在于各种恶性肿瘤中，人们认为它在癌症的发生和进展中发挥着重要作用。 CD10 的调节表达对于血管生成等是必需的。然而，它的表达水平被发现在不同的癌症中失调。在某些癌症中，它充当肿瘤抑制剂并抑制肿瘤进展，而在其他癌症中，它具有促进肿瘤的倾向。然而，其在肿瘤发生中的作用仍不清楚。这篇综述总结了 CD10 的结构特征、功能以及在癌症发展中可能发挥的作用。
The human CD10 antigen is a single pass, type II transmembrane, 100 kD cell surface glycoprotein belonging to peptidase M13 family. Identified in common acute lymphoblastic leukemia as a cancer specific antigen, CD10 is a cell surface ectoenzyme widely expressed on different types of cells. Earlier, it was used only as a cell surface marker to identify and differentiate between haematological malignancies. Later, reported to be present in various malignancies, it is thought to play significant role in cancer development and progression. Regulated expression of CD10 is necessary for angiogenesis and so forth. However its expression level is found to be deregulated in different cancers. In some cancers, it acts as tumor suppressor and inhibits tumor progression whereas in others it has tumor promoting tendency. However, its role in tumorigenesis remains unclear. This review summarises structural features, functions, and probable role of CD10 in cancer development.