Endothelial-to-Mesenchymal Transition in Atherosclerosis: Friend or Foe?
Endothelial-to-Mesenchymal Transition in Atherosclerosis: Friend or Foe?
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DOI：
10.3390/cells11192946
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发表时间：
2022-09-21
期刊：
影响因子：
6
通讯作者：
Cherepanova, Olga A.
中科院分区：
文献类型：
--
作者：
Gole, Sarin;Tkachenko, Svyatoslav;Masannat, Tarek;Baylis, Richard A.;Cherepanova, Olga A.
尽管经过数十年的研究，由不稳定斑块的破裂或侵蚀引起的动脉粥样硬化并发症仍然是全球死亡的主要原因。细胞谱系追踪技术的进步使研究人员能够开始研究单个细胞类型在调节斑块稳定性的关键过程中的作用，包括维持纤维帽，一种位于内皮下方的富含胶原蛋白的保护性结构。这种结构以前被认为是完全来自平滑肌细胞（SMC），从血管壁迁移。然而，最近的谱系追踪研究已经确定内皮细胞（EC）作为这种保护性屏障的重要组成部分，通过内皮-间充质转化（EndoMT），这是一个先前与肺，心脏和肾脏纤维化有关的过程。尽管几个实验室使用EC谱系追踪小鼠模型已经显示动脉粥样硬化斑块中存在EndoMT，但EndoMT是否有害（即，恶化的疾病进展）或有益的（即，防止斑块不稳定的动脉粥样硬化保护反应）仍然不确定，因为有数据支持这两种可能性，这将在本综述中进一步讨论。
Despite many decades of research, complications of atherosclerosis resulting from the rupture or erosion of unstable plaques remain the leading cause of death worldwide. Advances in cellular lineage tracing techniques have allowed researchers to begin investigating the role of individual cell types in the key processes regulating plaque stability, including maintenance of the fibrous cap, a protective collagen-rich structure that underlies the endothelium. This structure was previously thought to be entirely derived from smooth muscle cells (SMC), which migrated from the vessel wall. However, recent lineage tracing studies have identified endothelial cells (EC) as an essential component of this protective barrier through an endothelial-to-mesenchymal transition (EndoMT), a process that has previously been implicated in pulmonary, cardiac, and kidney fibrosis. Although the presence of EndoMT in atherosclerotic plaques has been shown by several laboratories using EC-lineage tracing mouse models, whether EndoMT is detrimental (i.e., worsening disease progression) or beneficial (i.e., an athero-protective response that prevents plaque instability) remains uncertain as there are data to support both possibilities, which will be further discussed in this review.
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DOI：
10.1161/atvbaha.118.311705
发表时间：
2018-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Al-Yafeai Z;Yurdagul A Jr;Peretik JM;Alfaidi M;Murphy PA;Orr AW
通讯作者：
Orr AW
影响因子：
7.8
作者：
Orr, A Wayne;Sanders, John M;Bevard, Melissa;Coleman, Elizabeth;Sarembock, Ian J;Schwartz, Martin Alexander
通讯作者：
Schwartz, Martin Alexander
影响因子：
11.1
作者：
Rohwedder, Ina;Montanez, Eloi;Beckmann, Karsten;Bengtsson, Eva;Duner, Pontus;Nilsson, Jan;Soehnlein, Oliver;Faessler, Reinhard
通讯作者：
Faessler, Reinhard
影响因子：
8.8
作者：
Chen PY;Qin L;Barnes C;Charisse K;Yi T;Zhang X;Ali R;Medina PP;Yu J;Slack FJ;Anderson DG;Kotelianski V;Wang F;Tellides G;Simons M
通讯作者：
Simons M
内皮 TGF-β 信号传导驱动血管炎症和动脉粥样硬化
影响因子：
20.8
作者：
Chen, Pei-Yu;Qin, Lingfeng;Simons, Michael
通讯作者：
Simons, Michael