Molecular, cellular and functional events in axonal sprouting after stroke.
Molecular, cellular and functional events in axonal sprouting after stroke.
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DOI：
10.1016/j.expneurol.2016.02.007
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发表时间：
2017-01
影响因子：
5.3
通讯作者：
Nie EH
中科院分区：
文献类型：
--
作者：
Carmichael ST;Kathirvelu B;Schweppe CA;Nie EH
中风是成人残疾的主要原因。然而，这种疾病的康复程度有限。恢复的机制之一是中风后大脑和脊髓中形成新的连接：中风后轴突萌发。研究表明，中风后轴突萌发发生在小鼠、大鼠、灵长类动物和人类身上。在特定连接中诱导卒中后轴突萌发可促进恢复；阻止轴突萌发损害恢复。中风后的行为活动模式改变了轴突萌发反应。一个独特的再生分子程序调节了中枢神经系统组织修复的这一方面。卒中后形成的连接类型表明卒中后轴突萌发的三种模式：反应性、修复性和无界性轴突萌发。它们在机制、位置、与行为恢复的关系上都不同，更重要的是，它们在治疗操作方面的前景不同，以增强组织修复。
Stroke is the leading cause of adult disability. Yet there is a limited degree of recovery in this disease. One of the mechanisms of recovery is the formation of new connections in the brain and spinal cord after stroke: post-stroke axonal sprouting. Studies indicate that post-stroke axonal sprouting occurs in mice, rats, primates and humans. Inducing post-stroke axonal sprouting in specific connections enhances recovery; blocking axonal sprouting impairs recovery. Behavioral activity patterns after stroke modify the axonal sprouting response. A unique regenerative molecular program mediates this aspect of tissue repair in the CNS. The types of connections that are formed after stroke indicate three patterns of axonal sprouting after stroke: Reactive, Reparative and Unbounded Axonal Sprouting. These differ in mechanism, location, relationship to behavioral recovery and, importantly, in their prospect for therapeutic manipulation to enhance tissue repair.