THE CHART TRIALS - BAYESIAN DESIGN AND MONITORING IN PRACTICE
THE CHART TRIALS - BAYESIAN DESIGN AND MONITORING IN PRACTICE
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DOI：
10.1002/sim.4780131304
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发表时间：
1994-07-15
影响因子：
2
通讯作者：
FREEDMAN, LS
中科院分区：
文献类型：
--
作者：
PARMAR, MKB;SPIEGELHALTER, DJ;FREEDMAN, LS
在本文中，我们描述了两个大型随机试验的设计和监测正在进行的英国医学研究理事会（MRC）癌症试验办公室。特别是，我们讨论的问题，在设计的试验，指定的零和备择假设，以及如何设计的影响所使用的监测程序。从这两个例子，和其他一些MRC的经验，我们提出了一些基本的考虑，可以适用于许多MRC和其他试验。
In this paper we describe the design and monitoring of two large randomized trials being conducted through the British Medical Research Council (MRC) Cancer Trials Office. In particular we discuss the issues involved in the design of the trials, specifying the null and alternative hypotheses and how the design has influenced the monitoring procedure used. From these two examples, and some other MRC experiences, we suggest some basic considerations which could be applied to many MRC and other trials.