COGNITIVE AND BEHAVIORAL DEFICITS IN NONHUMAN-PRIMATES ASSOCIATED WITH VERY EARLY EMBRYONIC BINGE EXPOSURES TO ETHANOL
COGNITIVE AND BEHAVIORAL DEFICITS IN NONHUMAN-PRIMATES ASSOCIATED WITH VERY EARLY EMBRYONIC BINGE EXPOSURES TO ETHANOL
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DOI：
10.1016/s0022-3476(05)81917-1
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发表时间：
1992-11-01
影响因子：
5.1
通讯作者：
SPELLMAN, D
中科院分区：
文献类型：
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作者：
CLARREN, SK;ASTLEY, SJ;SPELLMAN, D
本研究旨在评估早期每周乙醇暴露后妊娠期禁欲的致畸作用。在妊娠的前3周、6周或整个24周，每周经口给予妊娠的非人灵长类动物（Macaca nemestrina）1.8 gm/kg乙醇。对照动物每周接受一次蔗糖溶液，3周和6周队列动物在随后的几周也接受蔗糖溶液。对35名存活婴儿的生长、畸形、行为和认知功能障碍进行了评估。相对于对照动物，6周和24周队列中的动物行为一致异常，身体发育不一致异常。3周队列中的动物明显正常。这些结果表明，乙醇的能力，以产生行为致畸（脑功能障碍），从身体其他部位的物理异常隔离。研究结果强烈表明，在怀孕的前6至8周（女性可能不知道自己怀孕的时期）酗酒，然后在怀孕后期禁欲，对胎儿的危险性与整个妊娠期的暴露一样。
This study was undertaken to evaluate teratogenesis associated with early weekly ethanol exposure followed by later gestational abstinence. Ethanol, 1.8 gm/kg, was orally administered weekly to gravid nonhuman primates (Macaca nemestrina) for the first 3,6, or the entire 24 weeks of pregnancy. Control animals received weekly sucrose solution as did the 3- and 6-week cohort animals in subsequent weeks. Thirty-five viable infants were assessed for growth, malformations, and behavioral and cognitive dysfunction. Animals in the 6-week and 24-week cohorts were uniformly abnormal in behavior and inconsistently abnormal in physical development relative to the control animals. Animals in the 3-week cohort were equivocally normal. These results demonstrate ethanol's capacity to produce behavioral teratogenesis (brain dysfunction) in isolation from physical anomalies in the rest of the body. The results strongly suggest that binge drinking in the first 6 to 8 weeks of pregnancy (a period when women may not know that they are pregnant), followed by later gestational abstinence, is as dangerous to the fetus as exposure throughout gestation.