Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis.
Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis.
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DOI：
10.1093/aje/kwq480
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发表时间：
2011-04
影响因子：
5
通讯作者：
Zhi-Jiang Zhang;K. Hao;Rong Shi;Genming Zhao;G. Jiang;Yiqing Song;Xiaohui Xu;Jin Ma
中科院分区：
文献类型：
--
作者：
Zhi-Jiang Zhang;K. Hao;Rong Shi;Genming Zhao;G. Jiang;Yiqing Song;Xiaohui Xu;Jin Ma
谷胱甘肽S转移酶M1和谷胱甘肽S转移酶T1基因缺失与口腔癌之间的关系在多项研究中并不一致，而且缺乏它们与吸烟在口腔癌中相互作用的数据。作者系统地搜索了PubMed和SciVerse Scope，进行了病例对照研究，以检验GSTM1和GSTT1基因零基因与口腔癌的关系。确定了28项以英文发表的病例对照研究。汇总优势比通过随机效应模型得出。亚洲人GSTM1缺失的综合优势比为1.43(95%可信区间：1.14，1.78；P<；0.01，I(2)=73%)，高加索人为0.98(95%CI：0.76，1.28；P=0.91，I(2)=0)。对6项研究(552例)的病例分析显示，GSTM1缺失与吸烟(吸烟/高吸烟与从不吸烟/低吸烟)之间存在负相乘交互作用(优势比(OR)=0.51，95%CI：0.32，0.82；P=0.01，I(2)=34%)。在亚洲人(OR=1.07，95%CI：0.82，1.38；P=0.63，I(2)=65%)和高加索人(OR=1.04，95%CI：0.41，2.65；P=0.93，I(2)=55%)中，GSTT1缺失基因与口腔癌无显著相关性。总之，在亚洲人中，GSTM1零基因可能与口腔癌的高风险相关，而在高加索人中则不相关，而且这种影响可能会被吸烟状况所改变。GSTT1缺失基因可能与口腔癌无关。
The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of the GSTM1 and GSTT1 genes and oral cancer. Twenty-eight case-control studies published in English were identified. Summary odds ratios were derived via random-effects models. The summary odds ratio for the GSTM1 null genotype was 1.43 in Asians (95% confidence interval (CI): 1.14, 1.78; P < 0.01, I (2) = 73%) and 0.98 in Caucasians (95% CI: 0.76, 1.28; P = 0.91, I (2) = 0%). Case-only analysis of 6 studies (552 cases) showed an inverse multiplicative interaction between GSTM1 null polymorphisms and smoking (ever/high levels of smoking vs. never/low levels) (odds ratio (OR) = 0.51, 95% CI: 0.32, 0.82; P = 0.01, I (2) = 34%). The GSTT1 null genotype was not significantly associated with oral cancer in Asians (OR = 1.07, 95% CI: 0.82, 1.38; P = 0.63, I (2) = 65%) or Caucasians (OR = 1.04, 95% CI: 0.41, 2.65; P = 0.93, I (2) = 55%). In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status. The GSTT1 null genotype may not be associated with oral cancer.