Elderly-onset essential tremor is associated with dementia
Elderly-onset essential tremor is associated with dementia
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DOI：
10.1212/01.wnl.0000216134.88617.de
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发表时间：
2006-05-23
期刊：
影响因子：
9.9
通讯作者：
Bermejo-Pareja, Felix
中科院分区：
文献类型：
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作者：
Benito-Leon, Julian;Louis, Elan D.;Bermejo-Pareja, Felix
目的：探讨原发性震颤（ET）是否与流行性痴呆有关。研究方法：作者在西班牙中部的一项基于人群的研究中确定了所有患有痴呆症和ET的人（西班牙中部神经疾病[NEDICES]研究）。痴呆症是使用精神疾病诊断和统计手册（第4版）诊断的。的搜索.结果如下：273例ET患者中有31例（11.4%）患有痴呆，而3,382例非ET受试者（对照组）中有204例（6.0%）患有痴呆（比值比[OR] = 2.00，95% CI = 1.34至2.98，p = 0.001）。在调整年龄、中风和教育水平的模型中，OR = 1.35，95%CI = 0.87至2.18，p = 0.17。在校正模型中，65岁以后震颤发作的ET病例比对照组痴呆的可能性高70%（OR = 1.70，95%CI = 1.04 - 2.76，p = 0.03），而65岁以后震颤发作的ET病例
Objective: To determine whether essential tremor ( ET) is associated with prevalent dementia. Methods: The authors identified all persons with dementia and ET in a population-based study in central Spain ( the Neurological Disorders in Central Spain [NEDICES] Study). Dementia was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria. Results: Thirty-one (11.4%) of 273 ET cases had dementia vs 204 (6.0%) of 3,382 non-ET subjects (controls) (odds ratio [OR] = 2.00, 95% CI = 1.34 to 2.98, p = 0.001). In a model that adjusted for age, stroke, and educational level, OR = 1.35, 95% CI = 0.87 to 2.18, and p = 0.17. In an adjusted model, ET cases with tremor onset after age 65 were 70% more likely to be demented than were controls (OR = 1.70, 95% CI = 1.04 to 2.76, p = 0.03), whereas ET cases with tremor onset at age