Dynamics of Growth and Signaling along Linear and Surface Structures in Very Early Tumors
Dynamics of Growth and Signaling along Linear and Surface Structures in Very Early Tumors
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极早期肿瘤中沿线性和表面结构的生长和信号传导动力学
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
M. Kimmel
中科院分区：
文献类型：
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作者：
A. Marciniak;M. Kimmel
有证据表明，早期肿瘤沿线状、管状或不规则表面结构发展。非典型腺瘤性增生（AAH）是肺腺癌的前兆。我们之前发表了一个简化模型，该模型表明早期结构在潜伏期后具有自发侵袭性生长的潜力。癌细胞中生长因子的扩散和非线性细胞周期调节促进了这种转变。这种机制类似于图灵模式的形成，尽管这些模式是不规则和不稳定的。我们引入了更多生物学上合理的信号，其中只有自由生长因子分子扩散。模型中的柔性非线性可适应细胞的几种生长模式以及生长因子的内部与外部生产。我们证明了反应-扩散设置导致复杂的峰状解。我们根据美国医学协会发表的数据来讨论这些结果。
There exists evidence that in early stages tumors progress along linear, tubular, or irregular surface structures. This seems to be the case for atypical adenomatous hyperplasia (AAH), a precursor of adenocarcinoma of the lung. We previously published a simplified model, which showed that early structures had a potential towards spontaneous invasive growth following a latency phase. The transition was facilitated by diffusion of a growth factor and nonlinear cell cycle regulation in cancer cells. The mechanism is analogous to that in Turing pattern formation, although the patterns are irregular and unstable. We introduce more biologically justifiable signaling, in which only the free growth factor molecules diffuse. Flexible nonlinearities in the model accommodate several growth patterns of cells as well as internal versus external production of the growth factor. We show that the reaction-diffusion setup results in complicated spike-like solutions. We discuss these results in the light of published data on the AAH.