Endogenous postmenopausal hormones and serum lipids: The atherosclerosis risk in communities study
Endogenous postmenopausal hormones and serum lipids: The atherosclerosis risk in communities study
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DOI：
10.1210/jc.2004-0744
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发表时间：
2005-02-01
影响因子：
5.8
通讯作者：
Golden, SH
中科院分区：
文献类型：
--
作者：
Mudali, S;Dobs, AS;Golden, SH
先前的研究表明，外源性雌激素对血脂有有益的影响，然而，研究绝经后妇女内源性激素和血脂之间的关系产生了相互矛盾的结果。在动脉粥样硬化风险社区研究中，我们试图描述绝经后妇女中内源性激素和血脂参数之间的横截面关系，这些妇女患有显著（病例，n = 156）和轻微（对照，n = 172）颈动脉粥样硬化，未接受激素治疗。通过测量雌酮、总睾酮、雄烯二酮、硫酸脱氢表雄酮和SHBG水平评估内源性激素状态。使用游离雄激素指数（总睾酮/SHBG）估计游离睾酮。评估的血脂参数包括总胆固醇、甘油三酯、高密度脂蛋白（HDL）胆固醇和低密度脂蛋白（LDL）胆固醇。我们发现，SHBG与更有利的血脂谱显著相关，包括对照组中总胆固醇和低密度脂蛋白胆固醇和甘油三酯较低，高密度脂蛋白胆固醇较高。这种关联在SHBG仅与较高的甘油三酯和较低的HDL胆固醇相关的病例中不太突出。游离雄激素指数与致动脉粥样硬化的血脂水平相关，包括对照组中LDL胆固醇升高和病例中总胆固醇、LDL胆固醇和甘油三酯升高。这些关系是独立的人口和代谢因素和健康行为。在多变量分析中，与对照组相比，雌酮与较高的总胆固醇和甘油三酯相关。我们的数据表明，内源性性激素可能在调节绝经后妇女的脂质代谢中发挥作用。
Previous studies have revealed that exogenous estrogen has a beneficial effect on the lipid profile; however, studies examining the relation between endogenous hormones and lipid profiles in postmenopausal women have yielded conflicting results. We sought to characterize the cross-sectional relationship between endogenous hormones and lipid parameters in postmenopausal women with significant (cases, n = 156) and minimal (controls, n = 172) carotid atherosclerosis not taking hormone therapy in the Atherosclerosis Risk in Communities Study. Endogenous hormone status was assessed by measuring levels of estrone, total testosterone, androstenedione, dehydroepiandrosterone sulfate, and SHBG. Free testosterone was estimated using the free androgen index (total testosterone/SHBG). Lipid parameters assessed included total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol. We found that SHBG was significantly associated with a more favorable lipid profile, including lower total and LDL cholesterol and triglycerides and higher HDL cholesterol among controls. This association was less prominent among cases where SHBG was only associated with higher triglycerides and lower HDL cholesterol. The free androgen index was associated with a more atherogenic lipid profile, including increased LDL cholesterol among controls and increased total and LDL cholesterol and triglycerides among cases. These relations were independent of demographic and metabolic factors and health behaviors. In contrast to controls, estrone was associated with higher total cholesterol and triglycerides among cases in multivariate analyses. Our data suggest that endogenous sex hormones may play a role in regulating lipid metabolism in postmenopausal women.