Serum ferritin iron in iron overload and liver damage:: Correlation to body iron stores and diagnostic relevance
Serum ferritin iron in iron overload and liver damage:: Correlation to body iron stores and diagnostic relevance
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DOI：
10.1067/mlc.2000.106456
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发表时间：
2000-05-01
期刊：
影响因子：
--
通讯作者：
Düllmann, J
中科院分区：
文献类型：
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作者：
Nielsen, P;Günther, U;Düllmann, J
用铁蛋白免疫沉淀法和原子吸收光谱法测定铁含量，测定了正常或铁储量增加的患者血清铁蛋白的铁含量。结果与无创超导量子干涉装置（SQUID）生物磁仪测量的个体肝铁浓度相关，所有组患者血清铁蛋白蛋白浓度与铁蛋白铁浓度密切相关（r = 0.92）。在血色素沉着症患者（r = 0.63）和重度β -地中海贫血患者（r = 0.57）中，铁蛋白铁浓度与个体肝铁浓度的相关性较差，铁负荷患者的铁蛋白铁饱和度约为5%，这与最近的两项研究结果相反，但证实了以前的观察结果。血清铁蛋白铁饱和度明显高于铁超载组，可能表明细胞内富铁蛋白释放到血液中。骨髓移植患者的监测表明，富铁蛋白和贫铁蛋白的释放分别发生在肝细胞损伤和炎症期。我们发现血清铁蛋白铁测量对铁超载患者的益处不大。
The iron content of serum ferritin has been determined in groups of patients with normal or increased iron stores by using a technique of ferritin immunoprecipitation followed by iron quantitation with atomic absorption spectroscopy. The results were correlated to individual liver iron concentrations, measured non-invasively by superconducting quantum interference device (SQUID) biomagnetometry, A close correlation between serum concentrations of ferritin protein and ferritin iron was found (r = 0.92) in all groups of patients, However, the correlation between ferritin iron concentration and individual liver iron concentration was poor in patients with hemochromatosis (r = 0.63) and patients with beta-thalassemia major (r = 0.57), The degree of ferritin iron saturation was about 5% in iron-loaded patients, which contrasts with results in two recent studies but confirms older observations, In patients with liver cell damage, the ferritin iron saturation in serum was significantly higher than that found in groups with iron overload disease, probably indicating the release of intracellular iron-rich ferritin into the blood, The monitoring of patients undergoing bone marrow transplantation indicated that the release of iron-rich and Iron-poor ferritin occurred during phases of hepatocellular damage and inflammation, respectively, We find the benefits of serum ferritin iron measurement to be marginal in patients with iron overload disease.