PET activation of posterior temporal regions during auditory word presentation and verb generation
PET activation of posterior temporal regions during auditory word presentation and verb generation
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DOI：
10.1093/cercor/6.1.1
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发表时间：
1996-01-01
期刊：
影响因子：
3.7
通讯作者：
Petersen, SE
中科院分区：
文献类型：
--
作者：
Fiez, JA;Raichle, ME;Petersen, SE
先前使用正电子发射断层扫描（PET）的研究报告了与听觉和语言任务相关的颞上回和中回血流量变化（Petersen等人，1988,1989；Wise等人，1991；Demonet等人，1992；Howard等人，1992；Sergent等人，1992；Zatorre等人，1992；Petrides等人，1993；Raichle等人，1994；Fiez等人，1995）。一个重要的问题是，这些变化反映的是单个功能区的激活，还是具有不同功能贡献的多个功能区的激活。在本研究中，我们通过关注两个我们之前报道过的后颞血流量变化的任务来研究这个问题：听听觉呈现的单词（Petersen等人，1988年，1989年），以及对视觉呈现的名词产生一个动词（Raichle等人，1994年）；参见Wise等人（1991）。我们首先进一步描述了与听觉单词呈现相关的左颞顶叶区域的变化。这一先前报道的反应被重复了，并且通过证明假词的呈现也产生了激活而扩展了结果。我们接下来要问的是，与听觉单词呈现相关的激活是否可以与视觉名词呈现的动词生成相关的激活区分开来。研究发现，与这两个任务相关的激活可能在功能和空间上都是分离的。因此，两个与听觉单词呈现和动词生成相关的后颞区似乎代表了与文字处理相关的不同区域。更一般地说，结果证明了一种评估两个激活区域独立性的方法。
Previous studies using positron emission tomography (PET) report blood flow changes in superior and middle temple gyri associated with auditory and language tasks (Petersen et al., 1988, 1989; Wise et al., 1991; Demonet et al., 1992; Howard et al., 1992; Sergent et al., 1992; Zatorre et al., 1992; Petrides et al., 1993; Raichle et al., 1994; Fiez et al., 1995). An important issue is whether these changes reflect the activation of a single functional region or multiple regions with distinct functional contributions. In the present study, we examined this issue by focusing upon two tasks for which we have previously reported posterior temporal blood flow changes: listening to auditorily presented words (Petersen et al., 1988, 1989), and generation of a verb in response to a visually presented noun (Raichle ct al., 1994); see also Wise ct al. (1991). We began by further characterizing a left temporoparietal region of change previously associated with auditory word presentation. This previously reported response was replicated, and the results were extended by demonstrating presentation of pseudowords also produced activation. We next asked whether the activation associated with auditory word presentation could be distinguished from that associated with the generation of verbs in response to visually presented nouns. It was found that the activations associated with these two tasks could be both functionally and spatially dissociated. Thus, two posterior temporal areas associated with auditory word presentation and verb generation appear to represent distinct areas concerned with word processing. More generally, the results demonstrate an approach for assessing the independence of two activated areas.