Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study
Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study
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DOI：
10.1016/j.bone.2011.06.015
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发表时间：
2011-10-01
期刊：
影响因子：
4.1
通讯作者：
Wluka, Anita
中科院分区：
文献类型：
--
作者：
Brennan, S. L.;Pasco, J. A.;Wluka, Anita
前言：骨质疏松症与骨性关节炎(OA)之间的联系存在争议。虽然先前的研究已经表明全身、下肢、脊柱和膝关节的BMD与膝关节软骨体积呈正相关，但其他远距离特定部位的BMD测量方法与其他膝关节结构之间的关系尚不清楚。本研究的目的是确定无症状的中青年女性的8个骨骼部位的骨密度与膝关节结构的关系。方法：160名健康、无症状的女性(29-50岁)接受了膝关节的磁共振成像。采用双能X线骨密度仪测量脊柱、髋部、全身和前臂的骨密度，定量超声测量跟骨的骨密度。结果：腰椎、全身、股骨颈和Ward‘s三角的BMD与软骨体积、骨缺损量和骨髓病变(BMLS)呈正相关(P均<0.05)。
Introduction: The association between osteoporosis and osteoarthritis (OA) is controversial. Although previous studies have shown total body, lower limb, spinal and knee BMD and knee cartilage volume to be positively associated, the relationship between other distant site-specific measures of BMD and other knee structures is unknown. The aim of this study was to determine the associations between BMD at eight skeletal sites, and knee structure in asymptomatic young to middle-aged females without any clinical signs of OA.Methods: One hundred and sixty healthy, asymptomatic females (29-50 yr) underwent magnetic resonance imaging of the knee. BMD was measured at the spine, hip, total body and forearm by dual energy X-ray absorptiometry, and at the calcaneus by quantitative ultrasound. BMD was tested for an association with cartilage volume, defects, and bone marrow lesions (BMLs).Results: Medial cartilage volume was positively associated with BMD at the spine, total body, femoral neck, and Ward's triangle (all p