Does mast cell density predict the outcome after transurethral resection of Hunner's lesions in patients with type 3C bladder pain syndrome/interstitial cystitis?
Does mast cell density predict the outcome after transurethral resection of Hunner's lesions in patients with type 3C bladder pain syndrome/interstitial cystitis?
复制标题
肥大细胞密度是否可以预测 3C 型膀胱疼痛综合征/间质性膀胱炎患者经尿道切除 Hunner 病灶后的结果？
DOI：
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发表时间：
2010
影响因子：
--
通讯作者：
R. Peeker
中科院分区：
文献类型：
--
作者：
Josefine Rössberger;M. Fall;C. Gustafsson;R. Peeker
抽象目标。本研究的目的是评估肥大细胞密度在固有层可能与经尿道膀胱切除术（TURB）后症状改善的持续时间相关。材料和方法。该研究纳入了2003年6月至2009年6月期间转诊至三级转诊机构接受治疗的12名患者（8名女性和4名男性）。所有人都经历了连续三次完整的TURB手术，其中第一次也是诊断性的。所有患者均符合NIH-NIDDK标准和ESSIC膀胱疼痛综合征/间质性膀胱炎3C型标准;他们有Hunner病变和活检结果，包括炎性浸润、肉芽组织和肥大细胞增多症。通过免疫化学方法评价膀胱活检组织中肥大细胞密度，并通过症状复发的自我报告记录症状改善情况。结果在第一，第二和第三TURB固有层中的肥大细胞密度中位数较高。在第一次、第二次或第三次TURB后，尿道、固有层或逼尿肌中的肥大细胞密度与症状改善的持续时间之间无统计学显著相关性。结论肥大细胞密度似乎与经尿道完全切除Hunner病变后症状改善的持续时间无关，无论是在固有层还是在尿道或逼尿肌。
Abstract Objective. This study aimed to assess mast cell density in the lamina propria for possible correlation with duration of symptom amelioration after transurethral resection of the bladder (TURB). Material and methods. Twelve patients (eight women and four men) referred to the tertiary referral facility, treated between June 2003 and June 2009, were included in the study. All had undergone three consecutive complete TURB procedures, where the first one was also diagnostic. All patients fulfilled the NIH-NIDDK criteria and the ESSIC bladder pain syndrome/interstitial cystitis type 3C criteria; they had Hunner's lesions and biopsy findings with inflammatory infiltrates, granulation tissue and mastocytosis. Bladder biopsies were evaluated for mast cell density by immunochemistry and symptom amelioration was recorded by self-report of symptom relapse. Results. Median mast cell density in the lamina propria at the first, second and third TURB was high. No statistically significant correlation between mast cell density in the urothelium, lamina propria or detrusor, and duration of symptom amelioration could be seen after the first, second or third TURB. Conclusion. Mast cell density does not appear to correlate with duration of symptom amelioration after complete transurethral resection of Hunner's lesions, either in the lamina propria or in the urothelium or detrusor.
间质性膀胱炎中膀胱肥大细胞的激活：光学和电子显微镜研究。
DOI：
10.1097/00005392-199503000-00021
发表时间：
1995
期刊：
The Journal of urology
影响因子：
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作者：
Theoharides,TC;Sant,GR;el-Mansoury,M;Letourneau,R;UcciJr,AA;MearesJr,EM
通讯作者：
MearesJr,EM