Intersecting roles of protein tyrosine kinase and calcium signaling during fertilization.
Intersecting roles of protein tyrosine kinase and calcium signaling during fertilization.
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受精过程中蛋白酪氨酸激酶和钙信号传导的交叉作用。
DOI：
10.1016/j.ceca.2012.11.003
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发表时间：
2013-01
期刊：
影响因子：
4
通讯作者：
Kinsey WH
中科院分区：
文献类型：
--
作者：
Kinsey WH
The oocyte is a highly specialized cell that must respond to fertilization with a preprogrammed series of signal transduction events that establish a block to polyspermy, trigger resumption of the cell cycle and execution of a developmental program. The fertilization-induced calcium transient is a key signal that initiates the process of oocyte activation and studies over the last several years have examined the signaling pathways that act upstream and downstream of this calcium transient. Protein tyrosine kinase signaling was found to be an important component of the upstream pathways that stimulated calcium release at fertilization in oocytes from animals that fertilize externally, but a similar pathway has not been found in mammals which fertilize internally. The following review will examine the diversity of signaling in oocytes from marine invertebrates, amphibians, fish and mammals in an attempt to understand the basis for the observed differences. In addition to the pathways upstream of the fertilization-induced calcium transient, recent studies are beginning to unravel the role of protein tyrosine kinase signaling downstream of the calcium transient. The PYK2 kinase was found to respond to fertilization in the zebrafish system and seems to represent a novel component of the response of the oocyte to fertilization. The potential impact of impaired PTK signaling in oocyte quality will also be discussed.
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