Expression of Indian Hedgehog signaling molecules in breast cancer
Expression of Indian Hedgehog signaling molecules in breast cancer
复制标题
Indian Hedgehog信号分子在乳腺癌中的表达
DOI：
10.1007/s00432-008-0451-x
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发表时间：
2009-02-01
影响因子：
3.6
通讯作者：
Lin, Zhenhua
中科院分区：
文献类型：
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作者：
Xuan, Yanhua;Lin, Zhenhua
目的探讨Hedgehog（Hh）信号分子在乳腺癌和正常乳腺组织中的表达及其临床病理意义。材料与方法采用免疫组化方法检测21例正常乳腺组织和121例浸润性导管癌组织中Hh、Ptch、Smo、Gli-1、Gli-2、结果乳腺浸润性导管癌组织中Hh信号分子的表达均较正常乳腺组织明显增强。Ihh、Smo和Gli-2在PR阴性的乳腺癌中表达增高，且Ihh、Ptch和Gli-1/2/3的表达与Ki-67增殖指数增高相关。Ihh和Gli-1/2/3的表达与淋巴结转移有关。此外，Ihh、Ptch和Gli-2蛋白的表达与乳腺癌的临床分期有关。结论Hedgehog信号分子在乳腺浸润性导管癌的发生发展中起重要作用。
PurposeTo investigate the clinicopathological significance and expression pattern of Hedgehog (Hh) signaling molecules in breast normal glands and invasive ductal carcinoma.Materials and methodsA total of 142 cases, including 21 of normal breast and 121 of invasive ductal carcinoma of the breast, were immunohistochemically analyzed for Ihh, Ptch, Smo, Gli-1, Gli-2, and Gli-3 protein expression.ResultsAll of Hh signaling molecules were greatly enhanced in invasive ductal carcinoma compared with the normal breast epithelia. The expressions of Ihh, Smo, and Gli-2 were increased in PR negative cases, and the expressions of Ihh, Ptch, and Gli-1/2/3 were statistically correlated with increased proliferating index of Ki-67 in invasive ductal carcinoma. Ihh and Gli-1/2/3 expressions were correlated with node metastasis. Additionally, the protein expressions of Ihh, Ptch, and Gli-2 were correlated with the clinical stage of breast cancer.ConclusionsHedgehog signaling molecules play an important role in the progression of invasive ductal carcinoma of breast.