Contributions of Gaussian curvature and nonconstant lipid volume to protein deformation of lipid bilayers
Contributions of Gaussian curvature and nonconstant lipid volume to protein deformation of lipid bilayers
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DOI：
10.1529/biophysj.106.094953
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发表时间：
2007-02-01
影响因子：
3.4
通讯作者：
Brown, Frank L. H.
中科院分区：
文献类型：
--
作者：
Brannigan, Grace;Brown, Frank L. H.
提出了一个完整的膜蛋白引起的膜变形的弹性模型。一个较早的理论扩展到占非零鞍张开模量内的脂质单层和扰动的脂质体积接近的蛋白质。分析结果推导出的变形过程。le围绕单个圆柱形蛋白质内含物，其在蛋白质大小的范围内与粗粒度模拟相比是有利的。多蛋白质系统的数值结果表明，膜介导的夹杂物之间的相互作用的高斯曲率的强烈影响，并显示nonpairwise加性。蛋白质聚集的影响进行了讨论。
An elastic model for membrane deformations induced by integral membrane proteins is presented. An earlier theory is extended to account for nonvanishing saddle splay modulus within lipid monolayers and perturbations to lipid volume proximal to the protein. Analytical results are derived for the deformation pro. le surrounding a single cylindrical protein inclusion, which compare favorably to coarse-grained simulations over a range of protein sizes. Numerical results for multi-protein systems indicate that membrane-mediated interactions between inclusions are strongly affected by Gaussian curvature and display nonpairwise additivity. Implications for the aggregation of proteins are discussed.