Frailty, morbidity and survival
Frailty, morbidity and survival
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DOI：
10.1016/j.archger.2005.01.002
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发表时间：
2005-09-01
影响因子：
4
通讯作者：
Lee, KE
中科院分区：
文献类型：
--
作者：
Klein, BEK;Klein, R;Lee, KE
虚弱是身体储备减少的反映，而不是残疾，通过各种功能测试而不是特定的疾病负担来评估。我们在一项以中西部成年人为基础的人群研究中调查了虚弱程度与疾病结局和生存率的关系。我们评估的虚弱的标志物是：步行一个测量过程的时间（步态时间），握力，峰值呼吸流速，从坐姿站立而不使用手臂的能力，和最佳矫正视力。获得心血管疾病、癌症和高血压病史。在比弗坝眼科研究队列（n = 2962）的第三次检查（1998-2000）时收集数据。在1998-2000年检查后，对死亡率进行了长达4年半的随访。虚弱的标志物与年龄显著相关。将步态时间的最高四分位数（最慢）、呼气峰流速的最低四分位数、握力的最低四分位数、一次坐着不能站立（不坐轮椅的人）和视力障碍的值合并在一个指数中，以表示对虚弱的一般描述。指数范围为0（无虚弱）至5（最大虚弱）。更大的虚弱与心血管疾病和高血压显著相关。在调整年龄、性别、高血压、糖尿病和心血管疾病后，虚弱与4年半的生存率相关。更大的虚弱与更大的并发医疗状况的可能性和生存率降低相关。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Frailty, as a reflection of decreased physical reserve rather than disability, is assessed by various functional tests rather than by specific disease burden. We investigated association of measures of frailty to disease outcomes and survival in a population-based study of Midwestern adults. The markers of frailty we evaluated were: time to walk a measured course (gait-time), handgrip strength, peak respiratory flow rate, ability to stand from a sitting position without using arms, and best corrected visual acuity. A history of cardiovascular disease, cancer, and hypertension were obtained. Data were collected at the third examination (1998-2000) of the Beaver Dam Eye Study cohort (n = 2962). Follow-up for mortality occurred up to 4 1/2 years after the 1998-2000 examinations. Markers of frailty were significantly associated with age. Values in the highest quartile (slowest) of gait-time, lowest quartile of peak expiratory flow rate, lowest quartile of handgrip strength, inability to stand from sitting in one try (those not in a wheelchair), and visual impairment were combined in an index to denote a general description of frailty. The range of the index was 0 (no frailty) to 5 (maximum frailty). Greater frailty was significantly associated with cardiovascular disease and hypertension. Frailty was associated with poorer survival over an interval of 4 1/2 years after adjusting for age, sex, hypertension, diabetes, and cardiovascular disease. Greater frailty was associated with greater likelihood of concurrent medical conditions and with decreased survival. (c) 2005 Elsevier Ireland Ltd. All rights reserved.