Cytotoxic reactions associated with insect immunity.
Cytotoxic reactions associated with insect immunity.
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DOI：
10.1007/978-1-4615-1291-2_33
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发表时间：
2001
影响因子：
--
通讯作者：
A. Nappi;E. Vass
中科院分区：
文献类型：
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作者：
A. Nappi;E. Vass
昆虫和其他无脊椎动物缺乏脊椎动物特有的免疫球蛋白和适应性反应，但具有由细胞和体液成分组成的有效先天免疫系统（吉莱斯皮等人，1997年; Vilmos和Kurucz，1998年）。各种免疫学机制的进化起源和分子基础仍然是所有生物组织水平上最有趣的免疫学难题之一（Ratcliffe，1993; Ottaviani和Franceschi，1998）。通常，抵抗潜在侵入性生物体的第一道防线是表皮或中肠防御，其可能涉及由表皮细胞合成并转运至创伤部位的各种细胞毒性蛋白和抗微生物肽（Brey et al.，1993; Furukawa等人，1999年）。突破皮肤屏障或穿过肠壁侵入宿主血腔的外来生物体遇到反应性血细胞，以及一系列非特异性和特异性诱导细胞毒性分子。
Insects and other invertebrates lack the immunoglobulins and adaptive responses that characterize vertebrates yet possess efficient innate immune systems comprised of both cellular and humoral elements (Gillespie et al., 1997; Vilmos and Kurucz, 1998). The evolutionary origins and molecular basis for the various recognitive mechanisms remain among the most intriguing of immunological puzzles at all levels of biological organization (Ratcliffe, 1993; Ottaviani and Franceschi, 1998). Frequently, the first line of defense against potentially invasive organisms are integumental or midgut defenses, which may involve various cytotoxic proteins and antimicrobial peptides synthesized by epidermal cells and transported to the sites of wounding (Brey et al., 1993; Furukawa et al., 1999). Foreign organisms that breach integumental barriers or instead pass through the gut wall to invade the host’s hemocoel encounter reactive blood cells, and an array of both non-specific and specific inducible cytotoxic molecules.