Comparison of SPM and NEUROSTAT in voxelwise statistical analysis of brain SPECT and MRI at the early stage of Alzheimer's disease
Comparison of SPM and NEUROSTAT in voxelwise statistical analysis of brain SPECT and MRI at the early stage of Alzheimer's disease
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DOI：
10.1007/s12149-008-0211-7
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发表时间：
2008-12-01
影响因子：
2.6
通讯作者：
Sato, Noriko
中科院分区：
文献类型：
--
作者：
Nishimiya, Masaki;Matsuda, Hiroshi;Sato, Noriko
神经影像学在阿尔茨海默病（AD）的早期诊断中起着重要作用。最近的进展，体素统计分析后，解剖标准化的图像，使这种早期诊断更容易和更客观的视觉检查。我们目前比较观察神经，统计参数映射（SPM）99，我们对61例极早期AD患者和82例年龄较大的老年AD患者的脑灌注SPECT和MRI分割的灰质图像进行逐体素统计学分组分析。匹配健康志愿者。使用原始模板和常用模板，使用NEUROSTAT、SPM99和SPM2进行解剖标准化。无论使用哪种模板，这三种方法中SPECT的局部脑血流量（rCBF）显着减少的位置和MRI的灰质浓度是相同的。当使用原始模板时，SPM 99和SPM 2中扣带回后部峰值rCBF降低的显著性高于NEUROSTAT。另一方面，当使用共同模板时，NEUROSTAT和SPM 2中扣带回后部峰值rCBF降低的显著性高于SPM 99。NEUROSTAT显示所用模板之间峰值rCBF降低的显著性几乎相等。3种方法在海马旁回中观察到几乎相同的灰质浓度降低的显著性。NEUROSTAT、SPM 99和SPM 2在极早期AD患者中显示了相同的rCBF和灰质浓度显著降低的位置。所使用的解剖标准化模板与SPM中的体素统计分析结果相关，在SPM 2中不如SPM 99中显著，而在NEUROSTAT中不相关。
Neuroimaging plays a major role in the early diagnosis of Alzheimer's disease (AD). Recent advances in voxelwise statistical analysis after anatomic standardization of images have made this early diagnosis easier and more objective than visual inspection. We present comparative observations of NEUROSTAT, statistical parametric mapping (SPM) 99, and SPM2 in the early diagnosis of AD using brain perfusion single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI).We performed voxel-by-voxel statistical group analysis for brain perfusion SPECT and gray matter images segmented from MRI between 61 patients with very early AD and 82 age-matched healthy volunteers. Anatomic standardization was performed using NEUROSTAT, SPM99, and SPM2 using both original and common templates.The location of significant reduction of regional cerebral blood flow (rCBF) for SPECT and gray matter concentration for MRI were identical among these three methods irrespective of the templates used. When using the original template, the significance of peak rCBF reduction in the posterior cingulate gyri was higher in SPM99 and SPM2 than that in NEUROSTAT. On the other hand, when using the common template, the significance of peak rCBF reduction in the posterior cingulate gyri was higher in NEUROSTAT and SPM2 than that in SPM99. NEUROSTAT showed almost the equal significance of peak rCBF reduction between the used templates. Almost the equal significance of reduction in gray matter concentration was observed in the parahippocampal gyri among the three methods.NEUROSTAT, SPM99, and SPM2 showed identical location of significant reductions in rCBF and gray matter concentration in very early AD patients. Used templates for anatomic standardization are relevant to the results of voxelwise statistical analysis in SPM, less prominently in SPM2 than in SPM99, whereas irrelevant in NEUROSTAT.