Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes
Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes
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DOI：
10.1016/j.bbalip.2012.07.019
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Aidinis, Vassilis
中科院分区：
文献类型：
--
作者：
Sevastou, Ioanna;Kaffe, Eleanna;Aidinis, Vassilis
溶血磷脂酰胆碱（LPC）和溶血磷脂酸（LPA），最突出的溶血甘油磷脂，正在成为一类新的炎性脂质，加入血栓烷，白三烯和胰头素，它们共享代谢途径和调节机制。参与LK和LPA代谢的酶，例如磷脂酶A（2）超家族（PLA（2））和自分泌运动因子（ATX，ENPP 2），在调节LK和LPA水平以及因此它们的作用中起核心作用。本文将简要介绍LPC/LPA的生物合成途径，并综述LPC/LPA的信号传导特性及其在免疫系统和慢性炎症调节中的可能功能。此外，加重LPC和/或LPA信号在慢性炎症性疾病，即类风湿性关节炎，多发性硬化症，肺纤维化和肝炎的背景下，将讨论的影响。这篇文章是题为溶血磷脂研究进展的特刊的一部分。(C)2012爱思唯尔有限公司版权所有。
Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining thromboxanes, leukotrienes and prostaglandins with which they share metabolic pathways and regulatory mechanisms. Enzymes that participate in LK and LPA metabolism, such as the phospholipase A(2) superfamily (PLA(2)) and autotaxin (ATX, ENPP2), play central roles in regulating LK and LPA levels and consequently their actions. LPC/LPA biosynthetic pathways will be briefly presented and LPC/LPA signaling properties and their possible functions in the regulation of the immune system and chronic inflammation will be reviewed. Furthermore, implications of exacerbated LPC and/or LPA signaling in the context of chronic inflammatory diseases, namely rheumatoid arthritis, multiple sclerosis, pulmonary fibrosis and hepatitis, will be discussed. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. (C) 2012 Elsevier B.V. All rights reserved.