CORRELATION OF LABORATORY STUDIES WITH CLINICAL RESPONSES TO A-NEW-JERSEY INFLUENZA VACCINES
CORRELATION OF LABORATORY STUDIES WITH CLINICAL RESPONSES TO A-NEW-JERSEY INFLUENZA VACCINES
复制标题
DOI：
10.1093/infdis/136.supplement_3.s397
复制
发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
SCHILD, GC
中科院分区：
文献类型：
--
作者：
ENNIS, FA;MAYNER, RE;SCHILD, GC
对甲型流感/新泽西疫苗进行的大规模、统一的临床研究为将疫苗的实验室检测结果与人的反应性和抗体反应联系起来提供了机会。这些疫苗在编码下给予大量受试者，在未启动的个体中观察到免疫原性和反应性的显着差异。在未引物的受试者中，单个、相对大剂量的完整病毒比分裂病毒疫苗更具免疫原性和反应性。未引物受试者的免疫原性和反应性差异与疫苗中完整病毒的数量（通过柱层析或电子显微镜测量）和疫苗中病毒血凝素的数量（通过免疫扩散测量）相关，但与鸡细胞凝集单位的数量无关。
The large, uniformly performed clinical investigations with influenza A/New Jersey vaccines provided an opportunity to correlate results of laboratory tests of vaccines with human reactivity and antibody responses. These vaccines were given to large numbers of subjects under code, and significant differences in immunogenicity and reactivity were observed in unprimed individuals. A single, relatively large dose of intact virus was more immunogenic and reactive than split-virus vaccines in unprimed subjects. Differences in immunogenicity and reactivity in unprimed subjects correlated with the amount of intact virus in the vaccines (measured by column chromatography or electron microscopy) and with the amount of viral hemagglutinin in the vaccine (measured by immunodiffusion), but not with the number of chick cell-agglutinating units.