Stability of cough reflex sensitivity during viral upper respiratory tract infection (common cold)
Stability of cough reflex sensitivity during viral upper respiratory tract infection (common cold)
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DOI：
10.1016/j.pupt.2014.05.004
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发表时间：
2014-08-01
影响因子：
3.2
通讯作者：
Poore, Cathy L.
中科院分区：
文献类型：
--
作者：
Dicpinigaitis, Peter V.;Tibb, Amit S.;Poore, Cathy L.
咳嗽是与急性病毒性上呼吸道感染（URI）（如普通感冒）相关的最常见症状之一。两个先前的研究结合辣椒素咳嗽激发方法已经证明，咳嗽反射的敏感性是短暂的增强在URI。这些研究在URI期间使用咳嗽反射敏感性的单一测量。据我们所知，没有以前的研究包括多次测量咳嗽反射敏感性辣椒素在一个URI，以评估这一措施的稳定性，在急性病毒性疾病，在目前的方法学调查，我们进行了辣椒素咳嗽挑战42例受试者URI谁是健康的，成年人，非吸烟者（25名女性）。受试者在发病后72小时内入组，并随机分配至3组（每组n = 14），第1组在第0天和第1天;第2组在第2天和第3天;第3组在第4天和第5天进行咳嗽反射敏感性测量（C-2和C-5）。每名受试者在病毒感染后4-8周返回，以建立健康的基线测量（恢复）。我们的结果支持咳嗽反射对辣椒素的敏感性，如通过C-5测量的，是一种敏感的测量方法，在URI的6天内保持稳定。这些结果表明，在存在URI的情况下，咳嗽反射敏感性测量提供了一种敏感且可重复的方法，可用于未来寻求测试实验性止咳疗法的研究。(C)2014爱思唯尔有限公司版权所有。
Cough is among the symptoms most commonly associated with an acute, viral upper respiratory tract infection (URI), such as the common cold. Two previous studies incorporating capsaicin cough challenge methodology have demonstrated that cough reflex sensitivity is transiently enhanced during URI. These studies used single measurements of cough reflex sensitivity during the URI period. To our knowledge, no previous studies have included multiple measurements of cough reflex sensitivity to capsaicin during a URI to evaluate the stability of this measure during the acute viral illness.In the current methodological investigation, we performed capsaicin cough challenges in 42 subjects with URI who were otherwise healthy, adult, nonsmokers (25 female). Subjects were enrolled within 72 h of onset of illness and randomly assigned to 3 groups (n = 14 each) that underwent cough reflex sensitivity measurement (C-2 and C-5) at days 0 and 1 for group 1; days 2 and 3 for group 2; or days 4 and 5 for group 3. Each subject returned 4-8 weeks post-viral infection to establish a healthy baseline measurement (recovery).Our results support that cough reflex sensitivity to capsaicin, as measured by C-5, is a sensitive measure that remains stable during 6 days of a URI. These results suggest that cough reflex sensitivity measures in the presence of a URI provide a sensitive and reproducible approach that could be used in future investigations seeking to test experimental antitussive therapies. (C) 2014 Elsevier Ltd. All rights reserved.