Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women
Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women
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DOI：
10.1194/jlr.m014738
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发表时间：
2011-10-01
影响因子：
6.5
通讯作者：
Astrup, Arne
中科院分区：
文献类型：
--
作者：
Bendsen, Nathalie T.;Stender, Steen;Astrup, Arne
在横断面研究中，工业生产的反式脂肪酸（IP-TFA）的消耗与低度炎症和内皮功能障碍的全身标志物呈正相关，但干预研究的结果并不确定。因此，我们进行了一项为期16周的双盲平行干预研究，目的是检查IP-TFA摄入对炎症、氧化应激和内皮功能障碍的生物标志物的影响。52名健康超重的绝经后妇女（49名完成者）被随机分配接受部分氢化大豆油（15.7 g/天IP-TFA）或不含IP-TFA的对照油。16周后，与对照组相比，IP-TFA摄入使IP-TFA组的基线校正血清肿瘤坏死因子（TNF）α增加了12% [95%置信区间（CI）：5-20; P = 0.002]。血浆可溶性TNF受体1和2也通过IP-TFA增加[分别为155 pg/ml（CI：63-247）; P < 0.001和480 pg/ml（CI：72-887）; P = 0.02]。血清C-反应蛋白、白细胞介素（IL）6和脂联素以及皮下腹部脂肪组织IL 6、IL 8、TNF α和脂联素的mRNA表达以及神经酰胺含量不受IP-TFA影响，尿8-异前列腺素-F-2 α也不受影响。总之，这项饮食试验表明，将饮食IP-TFA与心血管疾病联系起来的机制可能涉及TNF α系统的激活。Bendsen，N. T.，S. Stender，P. B. Szecsi，S. B。佩德森，S。巴苏湖I.赫尔格伦纽曼，T. M.拉森，S。B。Haugaard和A.阿斯特鲁普工业生产的反式脂肪对全身炎症标志物的影响：来自女性随机试验的证据。J. Lipid Res. 2011. 52：1821-1828.
Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on bio-markers of inflammation, oxidative stress, and endothelial dysfunction. Fifty-two healthy overweight postmenopausal women (49 completers) were randomly assigned to receive either partially hydrogenated soybean oil (15.7 g/day IP-TFA) or control oil without IP-TFA. After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) alpha by 12% [95% confidence interval (CI): 5-20; P = 0.002] more in the IP-TFA group compared with controls. Plasma soluble TNF receptors 1 and 2 were also increased by IP-TFA [155 pg/ml (CI: 63-247); P < 0.001 and 480 pg/ml (CI: 72-887); P = 0.02, respectively]. Serum C-reactive protein, interleukin (IL) 6 and adiponectin and subcutaneous abdominal adipose tissue mRNA expression of IL6, IL8, TNF alpha, and adiponectin as well as ceramide content were not affected by IP-TFA, nor was urinary 8-iso-prostaglandin-F-2 alpha. In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNF alpha system.-Bendsen, N. T., S. Stender, P. B. Szecsi, S. B. Pedersen, S. Basu, L. I. Hellgren, J. W. Newman, T. M. Larsen, S. B. Haugaard, and A. Astrup. Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women. J. Lipid Res. 2011. 52: 1821-1828.