EFFECTS OF IRON CHELATORS AND IRON OVERLOAD ON SALMONELLA INFECTION
EFFECTS OF IRON CHELATORS AND IRON OVERLOAD ON SALMONELLA INFECTION
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DOI：
10.1038/267063a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
GRAZIANO, JH
中科院分区：
文献类型：
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作者：
JONES, RL;PETERSON, CM;GRAZIANO, JH
在铁超载状态（如重型β地中海贫血）和溶血状态（如镰状细胞病或巴尔通体病）中观察到对传染病的易感性增加1，2。大肠杆菌、单核细胞增生李斯特菌、鼠伤寒沙门氏菌和其他病原体的毒力可以通过向宿主施用铁化合物来增加，并且转铁蛋白诱导的细菌生长抑制可以通过使转铁蛋白饱和来逆转3 -6。血浆和分泌型铁结合蛋白，如转铁蛋白和乳铁蛋白，可能通过限制铁对入侵病原体的可用性而在宿主防御中起作用7。许多微生物合成铁结合化合物时，很少的铁是available 8;这些化合物可能会与主机铁结合机制竞争。我们在此报道了铁螯合药物对正常和铁超载小鼠中鼠伤寒沙门氏菌感染中铁竞争的影响。去铁胺（DF），一种异羟肟酸，和2，3-二羟基苯甲酸（2，3-DHB），一种酚类铁螯合剂，代表两类铁螯合化合物，它们正在用于铁过载的螯合治疗中进行测试。我们的数据提供的证据表明，DF增加铁的可用性野生型。鼠伤寒沙门氏菌，促进细菌生长，从而增强毒力。
INCREASED susceptibility to infectious disease is observed in iron-overloaded states such asβ-thalassaemia major and in haemolytic states such as sickle cell disease or Bartonellosis1,2. The virulence ofEscherichia coli, Listeria monocytogenes, Salmonella typhimuriumand other pathogens can be increased by administration of iron compounds to the host, and transferrin-induced inhibition of bacterial growth can be reversed by saturating transferrin3–6. Plasma and secretory iron-binding proteins such as transferrin and lactoferrin may function in host defence by limiting the availability of iron to invading pathogens7. Many microorganisms synthesise iron-binding compounds when little iron is available8; these compounds may compete with host iron-binding mechanisms. We report here the effects of iron-chelating drugs on this competition for iron inS. typhimuriuminfection in normal and iron-overloaded mice. Desferrioxamine (DF), a hydroxamic acid, and2,3-dihydroxy-benzoic acid (2,3-DHB), a phenolic iron chelator, represent two classes of iron-chelating compounds which are being tested in chelation therapy for iron overload. Our data provide evidence that DF increases iron availability to wild typeS. typhimurium, promoting bacterial growth and thus enhancing virulence.