Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
复制标题
分生孢子菌酮 H 和 I，来自海洋源性内生真菌产黄青霉 QEN-24S 的环吡烷类两种新二萜
DOI：
10.1002/cbdv.201000378
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发表时间：
2011-09-01
影响因子：
2.9
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Gao, Shu-Shan;Li, Xiao-Ming;Wang, Bin-Gui
本文报道了两个新的四环二萜类化合物，即生孢子素H和I（分别为1和2），沿着的还有5个相关的同源物，分生孢子母B - D和F（分别为3-5和6）。产黄青霉（PenicilliumchrysogenumQEN-24 S）是一种内生真菌，来源于一种未鉴定的凹顶藻属海洋红藻，其培养物中含有1，2-二羟基喹啉（1，2-二羟基喹啉）和分生孢子素（7）。这些化合物的结构是建立在广泛的光谱分析的基础上。评价了这些二萜类化合物对四种细菌和一种病原真菌的抑制活性。分生孢子素B（3）对耐甲氧西林金黄色葡萄球菌（MRSA）、荧光假单胞菌、铜绿假单胞菌和表皮葡萄球菌（MIC值均为8 μ g/ml）具有较强的抗菌活性，而分生孢子素（7）对荧光假单胞菌和S.表皮（每种的MIC值为16 μ g/ml）。这是首次报道环扁烷型二萜类化合物的抗菌活性。
Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I (1 and 2, resp.), along with five related congeners, conidiogenones B - D and F (3-5 and 6, resp.) and conidiogenol (7), were characterized from the culture extracts of Penicillium chrysogenum QEN-24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B (3) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. aeruginosa, and Staphylococcus epidermidis (each with a MIC value of 8 mu g/ml), while conidiogenol (7) showed obvious activity against P. fluorescens and S. epidermidis (each with a MIC value of 16 mu g/ml). This is the first report on antimicrobial activity of cyclopiane diterpenes.