In vitro binding experiments with a Valerian, Hops and their fixed combination extract (Ze91019) to selected central nervous system receptors
In vitro binding experiments with a Valerian, Hops and their fixed combination extract (Ze91019) to selected central nervous system receptors
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DOI：
10.1016/j.phymed.2004.03.005
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发表时间：
2004-11-01
期刊：
影响因子：
7.9
通讯作者：
Brattström, A
中科院分区：
文献类型：
--
作者：
Abourashed, EA;Koetter, U;Brattström, A
固定的缬草-啤酒花提取物组合Ze 91019被用作睡眠辅助剂。虽然其确切的作用机制还不清楚，但早期的研究表明，缬草的中枢神经系统作用可能是通过与大脑中的GABA，褪黑激素和/或腺苷系统相互作用而发生的。然而，在睡眠疗法中使用啤酒花主要是基于传统用途和稀缺的科学信息。在这份报告中，结合的Ze 91019，和成分缬草和啤酒花提取物内，测试了14个亚型的5类中枢受体（多巴胺，5-羟色胺，褪黑激素，MCH和神经肽-Y）。结合亲和力可以在一些筛选的褪黑激素（ML 1和ML 2）和5-羟色胺（5-HT 4 e，5-HT 6和5-HT 7）受体亚型证明。(C)2004年由Elsevier GmbH出版。
The fixed valerian-hops extract combination Ze91019 is used as a sleep aid. Although its exact mechanism of action is not well understood, earlier studies indicate that the CNS effect of valerian might occur through interaction with the GABA, melatonin and/or the adenosine systems in the brain. The use of hops in sleep remedies, however, is mainly based on traditional use and scarce scientific information. In this report, the binding of Ze91019, and the component valerian and hops extracts within, was tested on 14 subtypes of five classes of central receptors (dopamine, serotonin, melatonin, MCH and neuropeptide-Y). Binding affinities could be demonstrated at some of the screened melatonin (ML1 and ML2) and serotonin (5-HT4e, 5-HT6 and 5-HT7) receptor subtypes. (C) 2004 Published by Elsevier GmbH.