Anger, anxiety, and depressive affect as predictors of stress-induced cortisol production in khat and tobacco users.
Anger, anxiety, and depressive affect as predictors of stress-induced cortisol production in khat and tobacco users.
复制标题
愤怒、焦虑和抑郁是阿拉伯茶和烟草使用者压力诱发的皮质醇产生的预测因子。
DOI：
10.1016/j.addbeh.2018.02.033
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发表时间：
2018
影响因子：
4.4
通讯作者：
al'Absi,Mustafa
中科院分区：
文献类型：
--
作者：
Lemieux,AndrineM;Nakajima,Motohiro;Saif-Ali,Riyadh;Al-Habori,Molham;Dokam,Anisa;al'Absi,Mustafa
前言糖皮质激素活动在物质使用者中被破坏，包括也使用烟草的阿拉伯茶咀嚼者。愤怒、烦躁不安和焦虑可以调节这种关系。这项研究的目的是比较情绪失调和物质使用变量作为压力后皮质醇输出的预测因素。材料和方法男性(n = 90)和女性(n = 85)参与了一项压力研究，其中包括对照组、阿拉伯茶和同时吸食阿拉伯茶和烟草的人。在标准化的实验室压力操作后，收集了抑郁情绪、焦虑、愤怒、物质使用模式和唾液样本。结果回归分析表明，高度抑郁和低焦虑与高应激后皮质醇有关，但仅在烟草和阿拉伯茶的共同使用者中。男性，而不是女性，在同时使用阿拉伯茶和烟草和皮质醇之间显示出显著的关联，这似乎是由使用频率所调节的。在控制了尼古丁依赖和药物使用频率后，焦虑和压力后皮质醇之间的联系仍然显著。结论焦虑可以预测同时使用烟草和阿拉伯茶的神经内分泌后果，而不是性别、尼古丁依赖、愤怒和药物使用频率。然而，性别差异与尼古丁依赖的差异有关。
IntroductionGlucocorticoid activity is disrupted in substance users including khat chewers who also use tobacco. Anger, dysphoria, and anxiety can mediate this relationship. The aim of this study was to contrast emotion dysregulation and substance use variables as predictors of post-stress cortisol output.Materials and methodsComparable numbers of males (n = 90) and females (n = 85) including controls, khat only, and concurrent khat and tobacco users participated in a stress study. Depressive affect, anxiety, anger, substance use patterns, and saliva samples were collected following a standardized laboratory stress manipulation.ResultsRegression analysis showed that high depression and low anxiety was associated with high post-stress cortisol, but only in co-users of tobacco and khat. Males, but not females, showed a significant association between co-use of khat and tobacco and cortisol, which appears to be mediated by frequency of use. The link between anxiety and post-stress cortisol in the co-users remained significant after controlling for nicotine dependence and substance use frequency.ConclusionAnxiety predicted the neuroendocrine consequences of concurrent use of tobacco and khat above and beyond sex, nicotine dependence, anger, and substance use frequency. Sex differences, however, are related to differences in nicotine dependence.