The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target.
The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target.
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DOI：
10.18632/oncotarget.10048
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发表时间：
2016-08-23
期刊：
影响因子：
--
通讯作者：
Trisciuoglio D
中科院分区：
文献类型：
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作者：
Di Martile M;Del Bufalo D;Trisciuoglio D
赖氨酸乙酰化是一种翻译后修饰，通过靶向组蛋白以及细胞核中的多种转录因子来调节基因转录。最近，一些报道已经证明，许多胞质蛋白质也被乙酰化，这种修饰，影响蛋白质的活性，定位和稳定性，对它们的细胞功能有深远的影响。有趣的是，乙酰化靶向的大多数非组蛋白蛋白与肿瘤发生相关。在这篇综述中，我们将分析赖氨酸乙酰化在不同细胞室中的功能意义，并将检查我们目前对赖氨酸乙酰转移酶家族的理解，突出这些酶及其底物在癌症中的生物学作用和预后价值。文章的后半部分将讨论靶向赖氨酸乙酰转移酶的分子在癌症治疗中的挑战和现状。
Lysine acetylation is a post-translational modification that regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. Recently, several reports have demonstrated that numerous cytosolic proteins are also acetylated and that this modification, affecting protein activity, localization and stability has profound consequences on their cellular functions. Interestingly, most non-histone proteins targeted by acetylation are relevant for tumorigenesis. In this review, we will analyze the functional implications of lysine acetylation in different cellular compartments, and will examine our current understanding of lysine acetyltransferases family, highlighting the biological role and prognostic value of these enzymes and their substrates in cancer. The latter part of the article will address challenges and current status of molecules targeting lysine acetyltransferase enzymes in cancer therapy.