Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children.
Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children.
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DOI：
10.1080/20469047.2017.1408738
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发表时间：
2018-11
影响因子：
1.8
通讯作者：
Van Den Anker JN
中科院分区：
文献类型：
--
作者：
Fuchs A;Bielicki J;Mathur S;Sharland M;Van Den Anker JN
2005 年低收入和中等收入国家 (LMIC) 疑似脓毒症治疗指南建议住院治疗并预防性肌注 (IM) 或静脉注射 (IV) 氨苄青霉素和庆大霉素。 2015 年，当无法转诊至医院时，建议建议肌内注射庆大霉素和口服阿莫西林。在抗菌药物耐药性日益增加的时代，有必要对治疗新生儿和儿童败血症的适当经验疗法进行更新审查（考虑到易感性模式、成本和不良事件风险）。使用系统文献综述和国际指南来确定有关（疑似）脓毒症治疗的已发表证据。确定了五项经过充分设计和有力的研究，比较了中低收入国家低风险社区新生儿和小婴儿的抗生素治疗。这些解决了目前世界卫生组织参考治疗的潜在简化问题，对于无法入院治疗的婴儿。尽管全球抗菌药物耐药率不断上升，但关于新生儿和医院获得性败血症儿童疑似败血症的治疗仍缺乏研究。目前的世界卫生组织指南支持对住院患者使用庆大霉素和青霉素，或者在无法转诊至医院时使用庆大霉素和阿莫西林（口服），这些指南符合现有证据和其他国际指南，并且没有强有力的证据可以改变这一点。在已知不敏感率较高的地区，单独使用头孢菌素或联合使用头孢菌素作为二线治疗的益处尚未明确。需要对新生儿和儿童医院获得性败血症进行进一步研究。
Guidelines from 2005 for treating suspected sepsis in low- and middle-income countries (LMIC) recommended hospitalisation and prophylactic intramuscular (IM) or intravenous (IV) ampicillin and gentamicin. In 2015, recommendations when referral to hospital is not possible suggest the administration of IM gentamicin and oral amoxicillin. In an era of increasing antimicrobial resistance, an updated review of the appropriate empirical therapy for treating sepsis (taking into account susceptibility patterns, cost and risk of adverse events) in neonates and children is necessary. Systematic literature review and international guidelines were used to identify published evidence regarding the treatment of (suspected) sepsis. Five adequately designed and powered studies comparing antibiotic treatments in a low-risk community in neonates and young infants in LMIC were identified. These addressed potential simplifications of the current WHO treatment of reference, for infants for whom admission to inpatient care was not possible. Research is lacking regarding the treatment of suspected sepsis in neonates and children with hospital-acquired sepsis, despite rising antimicrobial resistance rates worldwide. Current WHO guidelines supporting the use of gentamicin and penicillin for hospital-based patients or gentamicin (IM) and amoxicillin (oral) when referral to a hospital is not possible are in accordance with currently available evidence and other international guidelines, and there is no strong evidence to change this. The benefit of a cephalosporin alone or in combination as a second-line therapy in regions with known high rates of non-susceptibility is not well established. Further research into hospital-acquired sepsis in neonates and children is required.
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幸存的败血症运动：严重败血症和化粪池冲击管理的国际指南，2012年。
影响因子：
38.9
作者：
Dellinger RP;Levy MM;Rhodes A;Annane D;Gerlach H;Opal SM;Sevransky JE;Sprung CL;Douglas IS;Jaeschke R;Osborn TM;Nunnally ME;Townsend SR;Reinhart K;Kleinpell RM;Angus DC;Deutschman CS;Machado FR;Rubenfeld GD;Webb S;Beale RJ;Vincent JL;Moreno R;Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
通讯作者：
Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
DOI：
10.5863/1551-6776-20.2.90
发表时间：
2015-03-01
期刊：
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
影响因子：
--
作者：
Kuehn, Jemima;Ismael, Zareen;Sharland, Mike
通讯作者：
Sharland, Mike
影响因子：
2.9
作者：
Botha, JH;du Preez, M;Adhikari, M
通讯作者：
Adhikari, M
DOI：
10.1111/j.1365-3156.2011.02822.x
发表时间：
2011-09
期刊：
Tropical medicine & international health : TM & IH
影响因子：
--
作者：
Ashley EA;Lubell Y;White NJ;Turner P
通讯作者：
Turner P
影响因子：
3.7
作者：
Fuchs A;Zimmermann L;Bickle Graz M;Cherpillod J;Tolsa JF;Buclin T;Giannoni E
通讯作者：
Giannoni E