Computational models of blood flow in the circle of Willis.
Computational models of blood flow in the circle of Willis.
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DOI：
10.1080/10255840008907996
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发表时间：
2000-01-01
影响因子：
1.6
通讯作者：
Guthrie, A
中科院分区：
文献类型：
--
作者：
Ferrandez, A;David, T;Guthrie, A
威利斯圆的二维稳态模型已经被开发出来。为了模拟脑血管树的外周阻力，我们使用了多孔介质块。在不考虑动脉自调节作用的情况下，其有效阻力保持不变。然后用该模型模拟威利斯圈的不同常见异常，同时对右颈内动脉（ICA）施加一系列不同的边界条件。将总通量制成表格，并与临床测量和其他威利斯圈模型进行比较。并对相关的流体力学效应进行了观察和分析。该模型表明，如果使用适当的边界条件，CFD可以产生生理结果。我们可以为临床医生提供考虑不同程度右侧ICA狭窄异常的流量减少严重程度的优先列表。从这项研究中可以明显看出，血液通过威利斯圈的再分配主要是由大脑血管阻力的变化而不是局部动脉几何形状的变化驱动的。使用有效的外周阻力允许更真实的威利斯圈模型，但也强调需要更准确的方法来估计患者的血管阻力。
A two-dimensional, steady state model of the circle of Willis has been developed. To simulate the peripheral resistance of the cerebrovascular tree, blocks of porous media were used. Their effective resistance was kept constant, disregarding the effects of arterial auto-regulation. The model was then used to simulate different common abnormalities of the circle of Willis while a range of varying boundary conditions was imposed to the right internal carotid artery (ICA). The total flux was tabulated and compared favourably with both clinical measurements and other models of the circle of Willis. Relevant fluid dynamics effects were also observed and analysed. The present model demonstrates that the use of CFD can produce physiological results if the appropriate boundary conditions are used. We can provide clinicians with a priority list of the severity of the flux reduction for the considered abnormalities for different degrees of stenosis of the right ICA. From this study it is apparent that the redistribution of blood via the circle of Willis is mainly driven by changes in the vascular resistance of the brain rather than in the local arterial geometry. The use of valid peripheral resistances allows for a more realistic model of the circle of Willis but also highlights the need for more accurate means to estimate the vascular resistance of a patient.