Application of Ultrasound for Targeted Nanotherapy of Malignant Tumors.
Application of Ultrasound for Targeted Nanotherapy of Malignant Tumors.
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DOI：
10.1134/s1063771009040162
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发表时间：
2009-10-01
影响因子：
0.8
通讯作者：
Kennedy A
中科院分区：
文献类型：
--
作者：
Rapoport NY;Nam KH;Gao Z;Kennedy A
该文章描述了通过超声和负载阿霉素或紫杉醇的全氟戊烷纳米乳对实体瘤进行靶向化疗干预的研究。通过被动靶向，乳液的纳米液滴在肿瘤中积累。在肿瘤定向治疗超声的作用下，纳米液滴转化为蒸气微泡。在体内，纳米液滴强烈保留了负载的药物；然而，在超声介导的汽化作用下，他们将药物释放到肿瘤组织中，从而实现对肿瘤的有效靶向。接受这种治疗的肿瘤有效消退；然而，一段时间后，它们又复发了。复发性肿瘤比原发性肿瘤对重复治疗具有更强的抵抗力。目前，产生耐药性的原因和消除方法尚不清楚，正在调查中。
The article describes the study of targeted chemotherapeutic intervention on solid tumors by means of ultrasound and doxorubicin- or paclitaxel-loaded perfluoropentane nanoemulsions. Nanodroplets of the emulsions accumulated in a tumor by passive targeting. Under the action of a tumor-directed therapeutic ultrasound, the nanodroplets converted into vapor microbubbles. In vivo, the nanodroplets strongly retained the loaded drugs; yet, under ultrasound-mediated vaporization they released the drugs into the tumor tissue, thereby implementing effective targeting into the tumor. The tumors subjected to this treatment regressed effectively; however, after some time they recurred. The recurring tumors were more resistant to the repeated therapy than the primary ones. At present, the causes of of the resistance development and methods for its elimination are unclear and they are under investigation.