Tailoring Mechanical Properties of Sol-Gel Hybrids for Bone Regeneration through Polymer Structure
Tailoring Mechanical Properties of Sol-Gel Hybrids for Bone Regeneration through Polymer Structure
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DOI：
10.1021/acs.chemmater.6b01941
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发表时间：
2016-09-13
影响因子：
8.6
通讯作者：
Jones, Julian R.
中科院分区：
文献类型：
--
作者：
Chung, Justin J.;Li, Siwei;Jones, Julian R.
生物玻璃是第一种与骨骼形成化学键的合成生物材料。虽然生物活性玻璃支架可以模拟骨的多孔结构，但它们很脆弱。溶胶-凝胶衍生的杂化物可以克服这个问题，因为它们的纳米级二氧化硅和有机聚合物网络具有提供独特物理特性和控制均匀生物降解的潜力。甲基丙烯酸甲酯（MMA）和3-（三甲氧基硅基）甲基丙烯酸丙酯（TMSPMA）共聚物利用其自硬化性能作为杂化物的有机来源。然而，定义良好的聚（MMA-co-TMSPMA）结构对混合系统的影响尚未得到研究。本文采用可逆加成-断裂链转移（RAFT）聚合方法合成了线性、随机支链和星形甲基丙烯酸酯基共聚物。这些共聚物随后被用来制造杂化物。三维聚合物结构对力学性能有显著影响，在保持类似于溶胶-凝胶玻璃的抗压强度的同时，提供更高的破坏应变。星形共聚物SiO2杂化玻璃的韧性模量比溶胶-凝胶衍生的生物活性玻璃高9.6倍，杨氏模量低4.5倍。在体外细胞培养过程中，无论聚合物结构如何，MC3T3-E1成骨前体细胞都粘附在细胞表面。将星形聚合物引入无机有机杂化物中，为微调骨支架材料的物理特性开辟了可能性。
Bioglass was the first synthetic biomaterial that formed a chemical bond to bone. Although bioactive glass scaffolds can mimic bone's porous structure, they are brittle. Sol-gel derived hybrids could overcome this problem because their nanoscale conetworks of silica and organic polymer have the potential to provide unique physical properties and controlled homogeneous biodegradation. Copolymers of methyl methacrylate (MMA) and 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) have been used as an organic source for hybrids to take advantage of their self-hardening property. However, the effect of well-defined poly(MMA-co-TMSPMA) architecture in the hybrid system has not been investigated. Here, linear, randomly branched, and star shaped methacrylate based copolymers were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization method. These copolymers were then used to fabricate hybrids. The 3-D polymer structure had a significant effect on mechanical properties, providing higher strain to failure while maintaining a compressive strength similar to sol-gel glass. Star copolymer SiO2 hybrids had a modulus of toughness 9.6-fold greater and Young's modulus 4.5-fold lower than a sol-gel derived bioactive glass. During in vitro cell culture, MC3T3-E1 osteoblast precursor cells adhered on the surface regardless of the polymer structure. Introducing star polymers to inorganic organic hybrids opens up possibilities for the fine-tuning physical properties of bone scaffold materials.