Multiparametric MRI tissue characterization in clinical stroke with correlation to clinical outcome - Part 2
Multiparametric MRI tissue characterization in clinical stroke with correlation to clinical outcome - Part 2
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DOI：
10.1161/01.str.32.4.950
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发表时间：
2001-04-01
期刊：
影响因子：
8.3
通讯作者：
Patel, S
中科院分区：
文献类型：
--
作者：
Jacobs, MA;Mitsias, P;Patel, S
背景和目的-多参数MRI在病变内产生不同的区域，可能反映脑缺血组织损伤的异质性。本研究提出了一种新的模型的组织定征的基础上获得的组织之间的角度分离的应用程序与使用一个目标（无监督）的计算机分割算法实现了修改版本的迭代自组织数据分析技术（ISODATA）。我们测试这个模型的效用，以确定缺血组织在临床stroke. Methods磁共振参数扩散，T2，和T1加权成像（DWI，T2 WI，和T1 WI，分别）从10例患者在3个时间点（30研究）中风后：急性（小于或等于12小时），亚急性（3至5天），慢性（3个月）。测量美国国立卫生研究院卒中量表（NIHSS），并从ISODATA、DWI和T2 WI图中获得患者在每个时间点的体积。结果急性（小于或等于12小时）多参数ISODATA体积与急性（小于或等于12小时）DWI显著相关（r=0.96. P
Background and Purpose-Multiparametric MRI generates different zones within the lesion that may reflect heterogeneity of tissue damage in cerebral ischemia. This study presents the application of a novel model of tissue characterization based on an angular separation between tissues obtained with the use of an objective (unsupervised) computer segmentation algorithm implementing a modified version of the Iterative Self-Organizing Data Analysis Technique (ISODATA). We test the utility of this model to identify ischemic tissue in clinical stroke.Methods-MR parameters diffusion-, T2-, and T1-weighted imaging (DWI, T2WI, and T1WI, respectively) were obtained from 10 patients at 3 time points (30 studies) after stroke: acute (less than or equal to 12 hours), subacute (3 to 5 days), and chronic (3 months). The National Institutes of Health Stroke Scale (NIHSS) was measured, and volumes were obtained from the ISODATA, DWI, and T2WI maps on patients at each time point.Results-The acute (less than or equal to 12 hours) multiparametric ISODATA volume was significantly correlated with the acute (less than or equal to 12 hours) DWI (r=0.96. P