Non-Coding RNA and Frizzled Receptors in Cancer.
Non-Coding RNA and Frizzled Receptors in Cancer.
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DOI：
10.3389/fmolb.2021.712546
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发表时间：
2021
影响因子：
5
通讯作者：
Tennis MA
中科院分区：
文献类型：
--
作者：
Smith AJ;Sompel KM;Elango A;Tennis MA
卷曲受体在Wnt/β-catenin信号通路中的作用早已被认识，Wnt/β-catenin信号通路以其致瘤作用而闻名。最近对卷曲受体的研究包括了解这些受体在癌症中的非编码RNA （ncRNA）调控。越来越清楚的是，ncRNA分子对于调节致癌蛋白和肿瘤抑制蛋白的表达都很重要。三种最常见的ncRNA分子是微rna （mirna）、长链非编码rna （lncRNAs）和环状rna （circRNAs）。在这里，我们回顾了直接或间接影响卷曲蛋白表达和下游信号传导的ncRNA分子。探索这些相互作用强调了将ncRNA分子纳入针对卷曲受体的癌症预防和治疗策略的潜力。先前对卷曲受体和ncRNA的研究已经在癌症进展中发挥了强大的作用，但需要更多的研究来提供大量的临床前证据，将研究结果转化为临床应用。
Frizzled receptors have been long recognized for their role in Wnt/β-catenin signaling, a pathway known for its tumorigenic effects. More recent studies of frizzled receptors include efforts to understand non-coding RNA (ncRNA) regulation of these receptors in cancer. It has become increasingly clear that ncRNA molecules are important for regulating the expression of both oncogenic and tumor-suppressive proteins. The three most commonly described ncRNA molecules are microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Here, we review ncRNA molecules that directly or indirectly affect frizzled protein expression and downstream signaling. Exploring these interactions highlights the potential of incorporating ncRNA molecules into cancer prevention and therapy strategies that target frizzled receptors. Previous investigations of frizzled receptors and ncRNA have established strong promise for a role in cancer progression, but additional studies are needed to provide the substantial pre-clinical evidence required to translate findings to clinical applications.