Protein that induces cell differentiation causes nicks in double‐stranded DNA
Protein that induces cell differentiation causes nicks in double‐stranded DNA
复制标题
诱导细胞分化的蛋白质会在双链 DNA 中产生切口
DOI：
10.1016/0014-5793(86)80520-8
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发表时间：
1986
期刊：
影响因子：
3.5
通讯作者：
L. Sachs
中科院分区：
文献类型：
--
作者：
G. Weisinger;A. Korn;L. Sachs
骨髓造血细胞的生长和分化由不同的巨噬细胞和粒细胞诱导蛋白调节，这些蛋白诱导生长，而其他蛋白诱导分化。诱导分化的蛋白质而不是诱导生长的蛋白质与双链DNA结合。我们现在报告，纯化的髓样细胞分化诱导蛋白导致双链DNA中的单链断裂（切口）。这种DNA切口可以启动分化所需的基因表达的变化。
The growth and differentiation of myeloid hematopoietic cells are regulated by different macrophage and granulocyte inducing proteins, those that induce growth and others that induce differentiation. The proteins that induce differentiation but not those that induce growth bind to double‐stranded DNA. We now report that purified myeloid cell differentiation‐inducing protein causes single strand breaks (nicks) in double‐stranded DNA. This DNA nicking may initiate the changes in gene expression that are required for differentiation.