One-step facile surface engineering of hydrophobic nanocrystals with designer molecular recognition.
One-step facile surface engineering of hydrophobic nanocrystals with designer molecular recognition.
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DOI：
10.1021/ja304115q
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发表时间：
2012-08-15
影响因子：
15
通讯作者：
Tan W
中科院分区：
文献类型：
--
作者：
Chen T;Öçsoy I;Yuan Q;Wang R;You M;Zhao Z;Song E;Zhang X;Tan W
高质量的纳米晶体在生物医学应用方面已经显示出巨大的潜力。然而，由于它们通常是疏水性的，它们的使用受到复杂和低效的表面工程的极大限制，这些工程往往不能产生生物相容性的纳米晶体，这些纳米晶体在生物流体中聚集最小，并且对特定的生物分子有活性靶向。利用嵌合DNA分子，我们开发了一种一步简单的疏水纳米晶体表面工程方法。该过程简单而通用，可以生成具有多个配体的单个纳米晶体。此外，由此产生的纳米晶体可以主动和特异性地靶向从核酸到癌细胞的各种分子地址。总之，这里制定的战略在产生纳米晶体生物医学应用所需的关键技术方面具有很大的希望。
High quality nanocrystals have demonstrated substantial potential for biomedical applications. However, being generally hydrophobic, their use has been greatly limited by complicated and inefficient surface engineering that often fails to yield biocompatible nanocrystals with minimal aggregation in biological fluids and active targeting toward specific biomolecules. Using chimeric DNA molecules, we developed a one-step facile surface engineering method for hydrophobic Nanocrystals. The procedure is simple and versatile, generating individual nanocrystals with multiple ligands. In addition, the resulting nanocrystals can actively and specifically target various molecular addresses, varying from nucleic acids to cancer cells. Together, the strategy developed here holds great promise in generating critical technologies needed for biomedical applications of nanocrystals.