Neuronal or glial progeny:: Regional differences in radial glia fate
Neuronal or glial progeny:: Regional differences in radial glia fate
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DOI：
10.1016/s0896-6273(03)00116-8
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发表时间：
2003-03-06
期刊：
影响因子：
16.2
通讯作者：
Götz, M
中科院分区：
文献类型：
--
作者：
Malatesta, P;Hack, MA;Götz, M
在发育中的中枢神经系统（CNS）中普遍存在的胶质细胞类型放射状胶质细胞的前体功能在很大程度上是未知的。通过Cre/IoxP体内命运定位研究，我们发现放射状胶质细胞几乎产生所有皮层投射神经元，但不产生起源于腹侧端脑的中间神经元。与大脑皮层相比，基底神经节中很少有神经元起源于放射状胶质细胞，体外谱系分析显示，来自端脑背侧和腹侧的放射状胶质细胞的电位存在内在差异。这表明，放射状胶质细胞的后代不仅在脑区之间存在巨大差异，而且还包括中枢神经系统某些部分的大部分神经元。
The precursor function of the ubiquitous glial cell type in the developing central nervous system (CNS), the radial glia, is largely unknown. Using Cre/IoxP in vivo fate mapping studies, we found that radial glia generate virtually all cortical projection neurons but not the interneurons originating in the ventral telencephalon. In contrast to the cerebral cortex, few neurons in the basal ganglia originate from radial glia, and in vitro lineage analysis revealed intrinsic differences in the potential of radial glia from the dorsal and ventral telencephalon. This shows that the progeny of radial glia not only differs profoundly between brain regions but also includes the majority of neurons in some parts of the CNS.