Barbiturate therapy reduces nitrogen excretion in acute head injury.
Barbiturate therapy reduces nitrogen excretion in acute head injury.
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巴比妥疗法可减少急性颅脑损伤时的氮排泄。
DOI：
10.1097/00005373-198911000-00017
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Mullen,JL
中科院分区：
文献类型：
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作者：
Fried,RC;Dickerson,RN;Guenter,PA;Stein,TP;Gennarelli,TA;Dempsey,DT;Buzby,GP;Mullen,JL
本文观察了戊巴比妥对7例严重颅脑损伤（格拉斯哥昏迷评分4.7 ± 1.7）患者在伤后第一周内氮和能量代谢的影响。戊巴比妥组（n= 4）与对照组（n= 3）相比，测得的能量消耗（占预测值的百分比）显著较低（分别为76+/-23%vs132 +/-28%，p < 0.01）。同样，巴比妥类药物组24小时尿氮排泄量低于对照组（分别为11.2+/-4.0 gm vs 19.5+/-3.3 gm，p< 0.01）。巴比妥酸盐组和对照组之间的尿3-甲基组氨酸排泄量无统计学差异（分别为43+/-12 mcg/天vs 47+/-14 mcg/天，p= NS）。
The effect of pentobarbital on nitrogen and energy metabolism was evaluated in seven severely head-injured patients (Glasgow Coma Scale 4.7+/-1.7) within the first week postinjury. Measured energy expenditure (% of predicted) was significantly lower in the pentobarbital group (n= 4) versus control (n= 3)(76+/-23% versus 132+/-28%, respectively, p< 0.01). Similarly, 24-hour urinary nitrogen excretion was lower for the barbiturate group compared to control (11.2+/-4.0 gm versus 19.5+/-3.3 gm, respectively, p< 0.01). No statistical difference was noted for urinary 3-methylhistidine excretion between the barbiturate and control groups (43+/-12 meg/day versus 47+/-14 meg/day, respectively, p= NS).