STABILITY OF HETEROGENEITY OF MYOCARDIAL BLOOD-FLOW IN NORMAL AWAKE BABOONS
STABILITY OF HETEROGENEITY OF MYOCARDIAL BLOOD-FLOW IN NORMAL AWAKE BABOONS
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DOI：
10.1161/01.res.57.2.285
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发表时间：
1985-01-01
影响因子：
20.1
通讯作者：
ROWELL, LB
中科院分区：
文献类型：
--
作者：
KING, RB;BASSINGTHWAIGHTE, JB;ROWELL, LB
Regional myocardial blood flow has been thought to be relatively uniform, in accord with the singular function of myocardial cells. However, considerable spatial heterogeneity has been observed in the hearts of anesthetized animals and in isolated hearts. Studies were undertaken in a total of 13 baboons. There were 11 awake, healthy animals sitting in chairs at rest or feeding, some performed mild leg exercise (wheel turning), and others were subjected to whole body heating; 2 were anesthetized, methodological controls. Microspheres (15 .+-. 3 .mu.m diameter, 0.5 .times. 106/kg body wt) were injected via a catheter into the apex of the left ventricle while arterial blood was sampled at a constant rate for calculating cardiac output. Microspheres with different labels were injected at 6 intervals of 20 min to sever hours. On sacrifice, the hearts were sectioned into 204 locatable pieces (left ventricle, 168; right ventricle, 27; and atria, 9). Average resting myocardial flow was 2.1 .+-. 0.2 ml/g per min (mean .+-. SD, n = 11). Left and right ventricles and atria comprised 70 .+-. 2% (n = 13), 20 .+-. 2% and 10 .+-. 2%, respectively, of the total heart mass while receiving 80 .+-. 3%, 16 .+-. 2% and 4 .+-. 2% of the total myocardial flow. Thus, mean left ventricular flow was 114 .+-. 5% of the average for the whole heart, right ventricular was 81 .+-. 13%, and atrial flow was 41 .+-. 13%. Myocardial flow heterogeneity was marked; in left ventricle, regional flows ranged from 1/3-2 times the mean, the relative dispersion (= SD/mean) of regional flows, corrected for methodological scatter and temporal variation, was 0.33 .+-. 0.06 (n = 67) in the whole heart, 0.26 .+-. 0.07 in left ventricle, 0.32 .+-. 0.11 in right ventricle and 0.22 .+-. 0.19 in the atria. The pattern of regional flows in each heart tended to remain stable with time. In each piece averaged over time, the relative dispersion due to temporal heterogeneity was 0.11 .+-. 0.03 (n = 2040) in the whole heart, 0.09 .+-. 0.03 in the left ventricle, 0.15 .+-. 0.05 in the right ventricle, and 0.23 .+-. 0.06 in the atria. The degree of spatial heterogeneity of local myocardial flows in conscious primates is similar to that of anesthetized animals and isolated hearts, and is much greater than that due to temporal fluctuations.
