Apo E4/3-Rich Remnant Lipoproteins and Platelet Aggregation: A Case Report
Apo E4/3-Rich Remnant Lipoproteins and Platelet Aggregation: A Case Report
复制标题
富含 Apo E4/3 的残余脂蛋白和血小板聚集：病例报告
DOI：
10.1055/s-0037-1615081
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发表时间：
1998
影响因子：
6.7
通讯作者：
M. Nakashima
中科院分区：
文献类型：
--
作者：
A. Saniabadi;S. Takeich;N. Yukawa;Y. Nakajima;K. Umemura;M. Nakashima
图1猝死患者血浆制备的富含载脂蛋白E4/3的RLP诱导的血小板聚集。血小板抑制剂的预孵育时间为阿司匹林15 min，西洛他唑或2-氯腺苷（2ClAd）1 min。在禁食15小时后从8名无药物的健康人获得血液，并在静脉穿刺后30分钟内完成聚集试验。脂蛋白的剂量由载脂蛋白的浓度表示。对于296 μg蛋白质，RLP胆固醇和RLP甘油三酯的相应值分别为308 μg和548 μg。通过Student t检验，与赋形剂相比，† P< 0.002，* p< 0.0001;对于试剂，与单独RLP相比
Fig. 1 Platelet aggregation induced by apo E4/3-rich RLP prepared from plasma of a sudden death case. Pre incubation time for platelet inhibitors was 15 min for aspirin, 1 min for cilostazol or 2-chloroadenosine (2ClAd). Blood was obtained from 8 drug free healthy persons after a 15 h fasting and aggregation tests were completed within 30 min of venepuncture. The dose of lipoproteins is represented by the concentration of apolipoproteins. For 296 μg protein, the corresponding values for RLP cholesterol and RLP triglyceride were 308 μg and 548 μg respectively.† P< 0.002,* p< 0.0001 vs. vehicle; for agents, vs RLP alone, by Student’s t-test