Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function.
Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function.
复制标题
抑制抑制剂的抑制剂：阻断PKC-theta以增强调节性T细胞功能。
DOI：
10.1126/scisignal.3132pe24
复制
发表时间：
2010
影响因子：
7.3
通讯作者：
Wülfing,Christoph
中科院分区：
文献类型：
--
作者：
Roybal,KoleT;Wülfing,Christoph
蛋白激酶C θ（PKC-θ）是T细胞中表达的多种PKC亚型之一，对成熟效应T细胞的活化起重要作用。在T细胞活化过程中，PKC-θ被募集到T细胞与活化细胞相互作用伴侣、抗原呈递细胞或其合成替代物之间的界面。新的证据表明，PKC-θ功能在调节性T细胞中不同，调节性T细胞是抑制效应T细胞功能的T细胞亚群。在调节性T细胞中，PKC-θ抑制它们的功能，有趣的是，它与激活的细胞界面隔离。这一发现提出了几个普遍感兴趣的问题。PKC-θ的功能是否与其他PKC家族成员的功能重叠？效应T细胞和调节T细胞的相似信号系统在功能上有什么关键区别？PKC-θ在调节性T细胞中的不同定位是否驱动功能？
Protein kinase C θ (PKC-θ), one of many PKC isoforms expressed in T cells, is important for the activation of mature effector T cells. During T cell activation, PKC-θ is recruited to the interface between the T cell and the activating cellular interaction partner, the antigen-presenting cell or a synthetic substitute thereof. New evidence establishes that PKC-θ function differs in regulatory T cells, a T cell subset that suppresses the function of effector T cells. In regulatory T cells, PKC-θ inhibits their function and, intriguingly, is sequestered from the activating cellular interface. This finding raises several questions of general interest. Does PKC-θ function overlap with that of other PKC family members? What are the functionally critical distinctions in the similar signaling systems of effector and regulatory T cells? Does the divergent localization of PKC-θ in regulatory T cells drive function?