Overexpression of KLF13 and FGFR3 in oral cancer cells.
Overexpression of KLF13 and FGFR3 in oral cancer cells.
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DOI：
10.1159/000308303
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发表时间：
2010-06-01
影响因子：
1.7
通讯作者：
Gollin, S M
中科院分区：
文献类型：
--
作者：
Henson, B J;Gollin, S M
KLF13和FGFR3具有重要的细胞功能，并且被认为在癌症中发挥作用。KLF13是一种转录因子，是多种癌基因表达所必需的。FGFR3是成纤维细胞生长因子受体，其启动导致许多细胞途径活化的信号级联。在这里，我们发现KLF13和FGFR3在口腔癌细胞中过表达。我们还表明，人为降低KLF13和FGFR3的细胞水平会降低细胞增殖并增加对电离辐射的敏感性。这些数据表明，KLF13和FGFR3有助于口腔癌细胞的恶性程度，可能是早期检测和治疗的可能靶点的有用生物标志物。
KLF13 and FGFR3 have important cellular functions and each is believed to play a role in cancer. KLF13 is a transcription factor required for the expression of several oncogenes. FGFR3 is a fibroblast growth factor receptor that initiates a signaling cascade leading to the activation of numerous cellular pathways. Here we show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cancer cells and may be useful biomarkers for early detection and possible targets for therapy.