Solid-phase construction:: high efficiency dendrimer synthesis using AB3 isocyanate-type monomers
Solid-phase construction:: high efficiency dendrimer synthesis using AB3 isocyanate-type monomers
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DOI：
10.1016/s0040-4020(03)00463-0
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发表时间：
2003-05-26
期刊：
影响因子：
2.1
通讯作者：
Bradley, M
中科院分区：
文献类型：
--
作者：
Lebreton, S;How, SE;Bradley, M
固相合成是需要高浓度和过量试剂以及强制化学条件的反应的理想工具。一种这样的化学是树状聚合物构建所需的化学。本文报道了一系列对称AB（3）异氰酸酯型单体的合成，并用于固相合成三支化树枝状大分子。该方法不仅允许可分离的树枝状聚合物，而且可以产生用于多价呈现的高负载支持物和装置。(C)2003爱思唯尔科技有限公司版权所有。
Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation. (C) 2003 Elsevier Science Ltd. All rights reserved.