Does obesity affect febrile responsiveness?
Does obesity affect febrile responsiveness?
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DOI：
10.1038/sj.ijo.0801523
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发表时间：
2001-04-01
影响因子：
4.9
通讯作者：
Romanovsky, AA
中科院分区：
文献类型：
--
作者：
Ivanov, AI;Kulchitsky, VA;Romanovsky, AA
背景与目的：对感染的抵抗力下降和免疫力受损在肥胖的人和患有遗传性肥胖的啮齿动物中是常见的。由于棕色脂肪产热在肥胖啮齿类动物中也受到抑制，我们假设肥胖导致发热反应性降低。大肠杆菌脂多糖（10 μ g/kg）之间的Zucker FA/FA（肥胖由于瘦素受体缺陷）和FA/？（瘦）大鼠之间以及Otsuka Long-Evans德岛肥胖（OLETF;由于缺乏胆囊收缩素-A受体而肥胖）和Long-Evans德岛Otsuka（瘦）大鼠之间的比较。肥胖的Zucker FA/FA和OLETF大鼠的体重和脂肪含量增加，hyperglycidemia和hypercholesterolemia.RESULTS：无论是FA/FA，也不OLETF动物表现出发热反应降低，如果有的话，他们的发热往往高于那些在他们的瘦counters.CONCLUSION：肥胖本身并不导致解热。
BACKGROUND AND OBJECTIVE: A decreased resistance to infection and impairments of immunity are common in obese humans and in rodents with hereditary obesity. Since brown fat thermogenesis is also suppressed in obese rodents, we hypothesized that obesity leads to a decreased febrile responsiveness.METHODS: We compared the fever responses to intravenous E. coli lipopolysaccharide (10 mug/kg) between Zucker fa/fa (obese due to a defective leptin receptor) and Fa/? (lean) rats and between Otsuka Long - Evans Tokushima Fatty (OLETF; obese due to the lacking cholecystokinin-A receptor) and Long-Evans Tokushima Otsuka (lean) rats. Obesity of Zucker fa/fa and OLETF rats was verified by increased body mass and fat content, hypertriglyceridemia and hypercholesterolemia.RESULTS: Neither fa/fa nor OLETF animals exhibited a decreased febrile responsiveness; if anything, their fevers tended to be higher than those in their lean counterparts.CONCLUSION: Obesity per se does not lead to antipyresis.